Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

33 questions · 33 findings · 12 reviews

No studies found 10 · 30.3%GRADE not reported 10 · 30.3%Very low 6 · 18.2%Low 7 · 21.2%Moderate 0 · 0%High 0 · 0%

Pharmacological interventions vs placebo

Gastrointestinal adverse events · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: all ‐ gastrointestinal effects (e.g. constipation,… compared with placebo (very low certainty).

1 finding from 1 review

Pregabalin vs placebo

Treatment‐related adverse effects · adults and children with sickle cell disease experiencing neuropathic pain

It is very uncertain whether summary of findings ‐ Pharmacological intervention (pregabalin) changes treatment‐related adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Attention deficit hyperactivity disorder (ADHD)‐related drugs vs placebo

Adverse effects · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

It is very uncertain whether attention deficit hyperactivity disorder (ADHD)‐related drugs changes adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Neurohormones vs placebo

Adverse effects · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

It is very uncertain whether neurohormones changes adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Adverse effects · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Amifostine (intravenous) vs Amifostine (subcutaneous)

Adverse effects · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Atypical antipsychotics vs placebo

Adverse effects (AEs) · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

Atypical antipsychotics may leads to higher adverse effects (AEs) compared with placebo (low certainty).

1 finding from 1 review