Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

196 questions · 221 findings · 67 reviews

No studies found 33 · 14.9%GRADE not reported 86 · 38.9%Very low 53 · 24%Low 25 · 11.3%Moderate 19 · 8.6%High 5 · 2.3%

FLUPENTHIXOL DECANOATE vs GENERAL ORAL ANTIPSYCHOTICS

Adverse effects: general ‐ movement disorders ‐ requiring anticholinergic medication ‐ short term Numbers requiring anticholinergic medication · patients with schizophrenia or related psychoses

It is very uncertain whether FLUPENTHIXOL DECANOATE changes adverse effects: general ‐ movement disorders ‐ requiring… compared with ORAL ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

Intranasal steroid spray vs placebo

Adverse event: systemic corticosteroid side effects · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether topical (intranasal) steroids changes adverse event: systemic corticosteroid side effects compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Frequency of serious adverse effects 20 to 24 weeks · participants with moderate and severe acne

It is very uncertain whether the intervention changes frequency of serious adverse effects 20 to 24 weeks (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events Participants (n) reported adverse effects · patients with treating osteoarthritis

The intervention showed no clear difference in adverse events Participants (n) reported adverse effects (low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Maternal drug adverse effects (6 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID (single administration, any dose) changes maternal drug adverse effects (6 hours after administration) compared with paracetamol (very low certainty).

1 finding from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Tooth staining/discolouration (adverse effect) · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste showed no clear difference in adverse effects (tooth staining, Meckel Stain Score, 6 months) compared with fluoride toothpaste without triclosan; GRADE not reported.

1 finding from 1 review

Intervention not reported

Adverse events Participants (n) withdrew due to adverse effects · patients with treating osteoarthritis
1 finding from 1 review

Intervention not reported

Adverse events Participants (n) withdrew due to adverse effects · patients with treating osteoarthritis
1 finding from 1 review

Intervention not reported

Adverse events Participants (n) withdrew due to adverse effects · patients with treating osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Boswellia serrata vs valdecoxib

Withdrawals due to adverse events · patients with treating osteoarthritis

It is very uncertain whether boswellia serrata changes adverse events Participants (n) withdrew due to adverse effects compared with valdecoxib (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events Participants (n) withdrew due to adverse effects · patients with osteoarthritis

The intervention showed no clear difference in adverse events Participants (n) withdrew due to adverse effects (moderate certainty).

1 finding from 1 review