Cochrane · systematic review · CD009435
Oral isotretinoin for acne
Costa, CS, Bagatin, E, Martimbianco, ALC, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SkinAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 66.7%Low 1 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: participants with moderate and severe acne
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in acne severity assessed by a decrease in total inflammatory lesion count, measured in participants who were treated for a minimum period of 16 weeks (Changes from baseline in total inflammatory lesion count and number of participants... | no estimate extracted | 3 studies · 400 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Frequency of serious adverse effects 20 to 24 weeks | RR 3 [0.12, 72.98] | 3 studies · 400 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Improvement in acne severity assessed by physician's global evaluation 20 to 24 weeks | no estimate extracted | 2 studies · 351 participants | Low Downgraded: risk of bias, imprecision, indirectness |