Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

95 questions · 95 findings · 47 reviews

No studies found 25 · 26.3%GRADE not reported 11 · 11.6%Very low 22 · 23.2%Low 21 · 22.1%Moderate 10 · 10.5%High 6 · 6.3%

Primary outcome: topical local anaesthetics vs infiltrated local anaesthetics or other topical agents

Anaesthetic‐related adverse effects · adults and paediatric patients with dermal laceration

Primary outcome: topical local anaesthetics led to lower anaesthetic‐related adverse effects compared with infiltrated local anaesthetics or other topical agents; GRADE not reported.

1 finding from 1 review

POLYPEPTIDE ‐ CERULETIDE vs placebo

Adverse effects ‐ any adverse effect · female and male 55‐59 year old (mean) patients with various psychiatric conditions and antipsychotic‐induced tardive dyskinesia

POLYPEPTIDE ‐ CERULETIDE showed no clear difference in adverse effects ‐ any adverse effect compared with PLACEBO (low certainty).

1 finding from 1 review

Switch to another antipsychotic vs antipsychotic cessation

Adverse effects: use of antiparkinsonism drugs · psychiatric patients (schizophrenia) with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether switch to another antipsychotic changes adverse effects: use of antiparkinsonism drugs compared with antipsychotic cessation (very low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Adverse effects during antidepressant treatment period (0‐12 weeks) · adults living with HIV and depression

It is very uncertain whether selective serotonin reuptake inhibitors (SSRI) changes adverse effects during antidepressant treatment period (0‐12 weeks) compared with tricyclic antidepressant (TCA) (very low certainty).

1 finding from 1 review

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults

S‐adenosyl methionine as monotherapy may leads to lower acceptability. Participants experiencing troublesome adverse effects… compared with tricyclic antidepressant agent (low certainty).

1 finding from 1 review

Intervention not reported

Total adverse effects Patient reported

The intervention showed no clear difference in total adverse effects Patient reported (low certainty).

1 finding from 1 review

Intervention not reported

Adverse effects necessitating stop of therapy Patient reported

The intervention probably leads to higher adverse effects necessitating stop of therapy Patient reported (moderate certainty).

1 finding from 1 review