What do systematic reviews say?

Systemic interventions (aciclovir, thalidomide, corticosteroids, rebamipide, etanercept, colchicine, interferon-alpha) vs placebo

• Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
  SoF 2 (systemic interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim; the review's wording "topical" is a typo for systemic): "8 placebo-controlled trials evaluated topical…
  Studies not reported
  GRADE not reported

ACT subsidies combined with supportive interventions vs no subsidies

• Subsidising artemisinin‐based combination therapy in the private retail sector 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 3 participants
  GRADE not reported

Oral miltefosine (50 mg for 28 days) vs 28 days on/off placebo regimen

Oral miltefosine (50 mg for 28 days) probably leads to higher adverse effects (number of participants who had the event) compared with placebo (same regimen) (moderate certainty).

• Interventions for American cutaneous and mucocutaneous leishmaniasis 2020 · Cochrane Headline outcomes only
  RR 3.96 [1.49, 10.48]
  1 study · 133 participants
  Moderate

Topical imiquimod 5% (3 times/week) + meglumine antimoniate (IVMA) (20 mg/kg/d for 20 days) vs placebo + IVMA

• Interventions for American cutaneous and mucocutaneous leishmaniasis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 80 participants
  High

Itraconazole (200 mg for 6 to 8 weeks) vs placebo

It is very uncertain whether itraconazole (200 mg for 6 to 8 weeks) changes adverse effects Mild abdominal pain and nausea Adverse effects Mild… compared with placebo (very low certainty).

• Interventions for Old World cutaneous leishmaniasis 2017 · Cochrane Headline outcomes only
  RR 2.36 [0.74, 7.47]
  3 studies · 204 participants
  Very low

Meglumine antimoniate (IMMA) (20 mg/kg/d for 20 days) vs placebo (3 tablets/4 times a day

Meglumine antimoniate (IMMA) (20 mg/kg/d for 20 days) probably leads to higher adverse effects (number of participants who had at least one adverse… compared with placebo (3 tablets/4 times a day (moderate certainty).

• Interventions for American cutaneous and mucocutaneous leishmaniasis 2020 · Cochrane Headline outcomes only
  RR 1.51 [1.17, 1.96]
  1 study · 134 participants
  Moderate

Topical treatments (benzydamine hydrochloride oral rinse) vs placebo

• Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes

  short-term (up to 3 months) · benzydamine hydrochloride
  SoF9. Adverse effects: single study narratively reported that no adverse effects occurred from benzydamine hydrochloride oral rinse; 20 participants (1 RCT); very low.
  1 study · 20 participants
  Very low

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

The review found no eligible studies for this question.

• Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Psychological therapies (cognitive therapy) vs placebo

The review found no eligible studies for this question.

• Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes

  short-term (up to 3 months)
  SoF8: No included study reported the occurrence of adverse events.
  0 studies
  No studies found

Low‐level laser therapy vs placebo

The review found no eligible studies for this question.

• Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes

  short-term (up to 3 months)
  SoF6: No included study reported the occurrence of adverse events.
  0 studies
  No studies found

Levamisole (150 mg per day) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
  Patients receiving levamisole reported more adverse effects than those receiving placebo (mild stomach upset/nausea, diarrhoea, sleeplessness, dysgeusia/dysosmia), however no adverse effects were reported as requiring…
  8 studies
  GRADE not reported

Sulodexide (heparin plus dermatan sulphate chains) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
  Sulodexide was not associated with significant adverse events.
  1 study · 20 participants
  GRADE not reported

LongoVital (herbal plus vitamin component) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  4 months
  Reported adverse events were minor and evenly distributed between the groups.
  1 study · 40 participants
  GRADE not reported

Prednisone (oral, commencing 25 mg with phased dose reduction over 2 months) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  2 months
  Femiano 2003: one significant adverse event (gastritis) for the prednisone group versus none for placebo. Femiano 2010: more drug-related adverse effects for those treated with prednisone than placebo.
  2 studies
  GRADE not reported

Sulodexide (heparin plus dermatan sulphate chains) vs prednisone

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
  Sulodexide was without significant adverse events; one significant adverse event (gastritis) was reported for the prednisone group.
  1 study · 20 participants
  GRADE not reported

Bee propolis (one 500 mg capsule per day) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  6 months (minimum)
  Propolis was associated with low rates of minimal side effects.
  1 study · 19 participants
  GRADE not reported

Individualised homeopathic medicine (two doses over 24 hours) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  6 days
  No participant needed to discontinue treatment due to adverse events.
  1 study · 100 participants
  GRADE not reported

Interactive computer intervention vs in‐person interventions

The review found no eligible studies for this question.

• Interactive computer‐based interventions for weight loss or weight maintenance in overweight or obese people 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Neurodynamic mobilisation vs no treatment

• Exercise and mobilisation interventions for carpal tunnel syndrome 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 14 participants
  Very low

Perilla cooking oil vs Soybean cooking oil

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  8 months
  No adverse events were reported.
  1 study · 33 participants
  GRADE not reported