Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

584 questions · 590 findings · 240 reviews

No studies found 106 · 18%GRADE not reported 94 · 15.9%Very low 137 · 23.2%Low 134 · 22.7%Moderate 98 · 16.6%High 21 · 3.6%

Droperidol vs placebo

Adverse effects ‐ cardiovascular ‐ arrhythmia · acute psychosis

Droperidol showed no clear difference in adverse effects ‐ cardiovascular ‐ arrhythmia compared with placebo (moderate certainty).

1 finding from 1 review

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs placebo or no intervention

Any adverse effects (e.g. hypervitaminosis A, as defined by the trialists) · preschool and school‐age children

Point‐of‐use fortification of foods with micronutrients powders (MNP) showed no clear difference in adverse effects (any, as defined by trialists) compared with no intervention or placebo (moderate certainty).

1 finding from 1 review

Dietary supplements (alpha lipoic acid +/- adjunctive ingredients) vs placebo

Adverse effects: intermittent facial skin rash · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether dietary supplements (alpha lipoic acid +/- adjunctive ingredients) changes adverse effects: intermittent facial skin rash compared with placebo (very low certainty).

1 finding from 1 review

Anticonvulsants (gabapentin 300 mg/day) vs placebo

Adverse effects: drowsiness (gabapentin alone) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether anticonvulsants (gabapentin 300 mg/day) changes adverse effects: drowsiness (gabapentin alone) compared with placebo (very low certainty).

1 finding from 1 review

RISPERIDONE vs placebo

Adverse events including extrapyramidal effects · terminally ill adults with delirium

Summary of findings: risperidone showed no clear difference in adverse events including extrapyramidal effectsd compared with placebo (low certainty).

1 finding from 1 review

Summary of findings: lorazepam plus haloperidol vs placebo plus haloperidol

Adverse events including extrapyramidal effects · terminally ill adults with severe delirium

It is very uncertain whether summary of findings: lorazepam plus haloperidol changes adverse events including extrapyramidal effectsd compared with placebo plus haloperidol (very low certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

Adverse events including extrapyramidal effects · terminally ill adults with delirium

Summary of findings: haloperidol showed no clear difference in adverse events including extrapyramidal effectse compared with placebo (moderate certainty).

1 finding from 1 review

Droperidol vs placebo

Adverse effects ‐ respiratory ‐ airway obstruction · acute psychosis

Droperidol showed no clear difference in adverse effects ‐ respiratory ‐ airway obstruction compared with placebo (low certainty).

1 finding from 1 review

Any antiglucocorticoid vs placebo

Adverse effects: 1. General ‐ overall number of events · people with psychosis

Any antiglucocorticoid probably leads to higher adverse effects: 1. General ‐ overall number of events compared with placebo (moderate certainty).

2 findings from 1 review