Cochrane · systematic review · CD010331
Topical anaesthesia for needle‐related pain in newborn infants
Foster, JP, Taylor, C, Spence, K · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 5 · 71.4%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
EMLA compared with placebo for needle‐related pain in newborn infants
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain using PIPP score EMLA vs placebo | no estimate extracted | 1 study · 38 participants | Low |
Pain using NIPS score EMLA vs placebo | no estimate extracted | 1 study · 38 participants | Low |
Successful venepuncture first attempt EMLA vs placebo | RR 0.98 [0.93, 1.03] | 1 study · 111 participants | Low |
Adverse effects (short‐lasting skin reactions) EMLA vs placebo | RR 1.65 [1.24, 2.19] | 3 studies · 272 participants | Low |
Amethocaine compared with placebo for needle‐related pain
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain Amethocaine vs placebo | no estimate extracted | 1 study · 110 participants | Low |
Successful cannulation first attempt Amethocaine vs placebo | RR 1.21 [0.82, 1.81] | 1 study · 39 participants | Very low |
Adverse effects (short‐lasting skin reactions) Amethocaine vs placebo | no estimate extracted | 3 studies · 181 participants | Moderate |