Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

403 questions · 428 findings · 117 reviews

No studies found 135 · 31.5%GRADE not reported 107 · 25%Very low 90 · 21%Low 44 · 10.3%Moderate 45 · 10.5%High 7 · 1.6%

Surgical vs non‐surgical treatment

Adverse effects of treatment Overall incidence of complications · people with lateral patellar dislocation

It is very uncertain whether surgical changes adverse effects of treatment Overall incidence of complications compared with non‐surgical treatment (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Adverse effects: neurological, extrapyramidal UKU (events) Medium‐term · people in the prodromal stage of psychosis

Group A: omega‐3 fatty acids showed no clear difference in adverse effects: neurological, extrapyramidal UKU (events) Medium‐term compared with placebo (low certainty).

1 finding from 1 review

Topical vitamin D derivative vs placebo

Proportion of participants with adverse effects ‐ measured over 8 weeks · chronic palmoplantar pustulosis

Topical vitamin D derivative showed no clear difference in proportion of participants with adverse effects ‐ measured over 8… compared with placebo (moderate certainty).

1 finding from 1 review

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Any other adverse effects of the interventions, such as gingival disease and demineralisation · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

The review found no eligible studies for this question.

1 finding from 1 review

Extraction of the primary (baby) canine (single primary tooth extraction) vs No extraction (non-intervention control)

Any other adverse effects of the interventions, such as gingival disease and demineralisation · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

The review found no eligible studies for this question.

1 finding from 1 review

Etretinate vs placebo or no treatment

Proportion of participants with adverse effects ‐ measured over 8 weeks · chronic palmoplantar pustulosis

It is very uncertain whether etretinate changes proportion of participants with adverse effects ‐ measured over 12… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Etretinate with PUVA therapy as co‐intervention vs placebo with PUVA therapy

Proportion of participants with adverse effects ‐ measured over 8 weeks · chronic palmoplantar pustulosis

It is very uncertain whether etretinate with PUVA therapy as co‐intervention changes proportion of participants with adverse effects ‐ measured over 20… compared with placebo with PUVA therapy (very low certainty).

1 finding from 1 review

Etretinate vs PUVA

Proportion of participants with adverse effects ‐ measured over 8 weeks · chronic palmoplantar pustulosis

It is very uncertain whether etretinate changes proportion of participants with adverse effects ‐ measured over 12… compared with PUVA therapy (very low certainty).

1 finding from 1 review

Alitretinoin vs placebo

Proportion of participants with adverse effects ‐ measured over 8 weeks · chronic palmoplantar pustulosis

Alitretinoin showed no clear difference in proportion of participants with adverse effects ‐ measured over 24… compared with placebo (moderate certainty).

1 finding from 1 review

Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion

Percentage of participants with adverse effects and severe adverse effects · guttate psoriasis

The review found no eligible studies for this question.

1 finding from 1 review