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Evidence found and GRADE certainty

377 questions · 402 findings · 108 reviews

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No studies found 114 · 28.4%GRADE not reported 107 · 26.6%Very low 88 · 21.9%Low 41 · 10.2%Moderate 45 · 11.2%High 7 · 1.7%

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Gastrointestinal adverse events · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

It is very uncertain whether summary of findings table ‐ Protein, arginine, zinc and antioxidants changes side effects: at least one adverse gastrointestinal event compared with standard diet or placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Arginine and micronutrients vs standard diet

Gastrointestinal adverse events · malnourished patients with pressure ulcers

It is very uncertain whether summary of findings table ‐ Arginine and micronutrients changes side effects: at least one adverse gastrointestinal event compared with standard diet (very low certainty).

1 finding from 1 review

Oral miltefosine (1.2 to 3.3 mg/kg/d 28 days) vs meglumine antimoniate (20 mg/kg 20 days)

Adverse effects (number of participants who had the event) · People with American cutaneous and mucocutaneous leishmaniasis

Oral miltefosine (1.2 to 3.3 mg/kg/d 28 days) probably leads to higher adverse effects (number of participants who had the event) compared with meglumine antimoniate (20 mg/kg 20 days) (moderate certainty).

1 finding from 1 review

Adalimumab every other week vs placebo

Proportion of participants with infectious adverse effects · participants with hidradenitis suppurativa

Adalimumab every other week showed no clear difference in proportion of participants with infectious adverse effects compared with placebo (high certainty).

1 finding from 1 review

Adalimumab weekly vs placebo

Proportion of participants with infectious adverse effects · participants with hidradenitis suppurativa

Adalimumab weekly showed no clear difference in proportion of participants with infectious adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Gentamicin sponge vs primary closure

Adverse effects ‐ complication rate at 1 week after surgery · participants with hidradenitis suppurativa

Gentamicin sponge showed no clear difference in adverse effects ‐ complication rate at 1 week after surgery compared with primary closure alone (moderate certainty).

1 finding from 1 review

Valaciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention · participants with recurrent herpes labialis

Valaciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention compared with placebo (moderate certainty).

1 finding from 1 review

Valaciclovir (suppressive regimen vs episodic regimen)

Adverse effects during use of the preventative intervention · participants with recurrent herpes labialis

It is very uncertain whether valaciclovir (suppressive regimen changes adverse effects during use of the preventative intervention compared with episodic regimen) (very low certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention compared with placebo (low certainty).

1 finding from 1 review

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyloestradiol and norgestrel

Number of participants reporting non‐serious adverse effects · participants with hidradenitis suppurativa

Ethinyloestradiol and cyproterone acetate probably leads to lower number of participants reporting non‐serious adverse effects compared with ethinyloestradiol and norgestrel (moderate certainty).

1 finding from 1 review

Gentamicin sponge vs primary closure

Adverse effects ‐ complication rate at 3 months after surgery · participants with hidradenitis suppurativa

Gentamicin sponge showed no clear difference in adverse effects ‐ complication rate at 3 months after surgery compared with primary closure alone (moderate certainty).

1 finding from 1 review