What do systematic reviews say?

Sodium bicarbonate rinse (plus toothbrushing) vs Water rinse (plus toothbrushing)

• Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
  Adverse effects (Berry 2011, CHX versus sodium bicarbonate versus water): no adverse events were reported associated with the interventions.
  1 study
  GRADE not reported

Povidone iodine rinse vs Saline rinse or placebo

• Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
  Adverse effects (Seguin 2014): no evidence of a difference in acute respiratory distress syndrome (RR 11.00, 95% CI 0.62 to 195.61), agitation and/or hypertension (RR 0.48, 95% CI 0.12 to 1.86), epistaxis (RR 0.14, 95%…
  1 study
  GRADE not reported

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs High-content fluoride toothpaste (1350 ppm)

• Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes

  14 to 36 months
  Adverse effects were an outcome of interest in the study conducting this comparison, however no mention was made of the presence or absence of any adverse events
  1 study · 220 participants
  Very low

1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily vs 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily

The review found no eligible studies for this question.

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond (end of orthodontic treatment)
  Additional SoF Table 2. Adverse effects: none of the trials reported this outcome.
  0 studies
  No studies found

Hyperbaric oxygen therapy (HBO) following extractions vs penicillin G

• Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes

  6 months
  Adverse effects were an outcome of interest in the study conducting this comparison, however no mention was made of the presence or absence of any adverse events
  1 study · 74 participants
  Very low

Patient-used 250 ppm F mouthrinse (100 ppm amine F/150 ppm NaF), daily vs 0 ppm F placebo mouthrinse, daily

The review found no eligible studies for this question.

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond (end of orthodontic treatment)
  SoF 4. Adverse effects: none of the trials reported this outcome.
  0 studies
  No studies found

Slow-release fluoride device (fluoride glass beads) vs Fluoride mouthrinse

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond; follow-up 19 months
  Additional SoF Table 3. Adverse effects: current design of the fluoride glass bead inadequate; high attrition partly due to bead breakages ('an improved method of attachment is needed'). 37 participants (1 RCT, Luther…
  1 study · 37 participants
  Very low

Resin-modified glass ionomer cement for bonding orthodontic brackets vs Composite resin for bonding brackets

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond; follow-up 17.6 months
  SoF 5. Adverse effects: no evidence that either intervention had adverse effects. 173 participants (1 RCT, Benson 2019); certainty LOW.
  1 study · 173 participants
  Low

Intervention not reported

The review found no eligible studies for this question.

• Preventive lipid‐based nutrient supplements given with complementary foods to infants and young children 6 to 23… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Preventive lipid‐based nutrient supplements given with complementary foods to infants and young children 6 to 23… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Patient-used 5000 ppm F toothpaste, daily vs 1450 to 1500 ppm F toothpaste

The review found no eligible studies for this question.

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond (end of orthodontic treatment)
  SoF 3. Adverse effects: none of the trials reported this outcome.
  0 studies
  No studies found

12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel vs Placebo gel

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond; mean follow-up 16.6 months
  Additional SoF Table 1. Adverse effects: with placebo gel 0.60%; with fluoride gel 0.00% (0 to 0); difference 0.60% fewer (0.60 fewer to 0.60 fewer); relative effect not estimable; 312 participants (1 RCT); certainty…
  1 study · 312 participants
  Very low

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

The review found no eligible studies for this question.

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond (end of orthodontic treatment)
  SoF 2. Adverse effects: none of the trials reported this outcome.
  0 studies
  No studies found

Fluoride varnish vs Non-fluoride (placebo) varnish

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond; follow-up 1.7 years
  SoF 1. Adverse effects: no evidence that the intervention had adverse effects; only 1 participant with an adverse event and unclear if directly related to the intervention. 148 participants (1 RCT, Sonesson 2019);…
  1 study · 148 participants
  Low

Multifactorial interventions vs exercise

The review found no eligible studies for this question.

• Multifactorial and multiple component interventions for preventing falls in older people living in the community 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Multi‐component intervention vs usual care or attention control

The review found no eligible studies for this question.

• Multifactorial and multiple component interventions for preventing falls in older people living in the community 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Multi‐component intervention vs exercise

The review found no eligible studies for this question.

• Multifactorial and multiple component interventions for preventing falls in older people living in the community 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Multifactorial interventions vs usual care or attention control

The review found no eligible studies for this question.

• Multifactorial and multiple component interventions for preventing falls in older people living in the community 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Resin-based fissure sealant (2nd/3rd/4th generation) vs No sealant (control/no treatment)

• Pit and fissure sealants for preventing dental decay in permanent teeth 2017 · Cochrane All outcomes
  Two trials measured adverse effects. None were reported.
  2 studies
  GRADE not reported

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
  No evidence of a difference in reported adverse events across the three trials (nausea, fever, constipation, diarrhoea, headache, fatigue and others)
  3 studies
  GRADE not reported