Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

780 questions · 834 findings · 76 reviews

No studies found 187 · 22.4%GRADE not reported 164 · 19.7%Very low 144 · 17.3%Low 172 · 20.6%Moderate 105 · 12.6%High 62 · 7.4%

Vitamin C vs placebo

Adverse effects (urticaria) Defined as participants reporting urticaria (hives) Dose: 2 g per day · school‐aged children (6 to 15 years) and marine corps recruits (mean age 18.5 years)

It is very uncertain whether vitamin C changes adverse effects (urticaria) Defined as participants reporting… compared with placebo (very low certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Adverse effect: hypercalciuria As defined by trialists Time frame: 3 months · children under 5 years of age

Vitamin D showed no clear difference in adverse effect: hypercalciuria As defined by trialistsTime frame:… compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Hypercalcaemia · children under 5 years of age

It is very uncertain whether vitamin D changes adverse effect: hypercalcaemia As defined by trialistsTime frame:… compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Vitamin E vs placebo

Tardive dyskinesia: No clinically important improvement · patients with antipsychotic‐induced tardive dyskinesia

VITAMIN E showed no clear difference in tardive dyskinesia: 1. Not improved to a clinically important extent compared with PLACEBO (low certainty).

1 finding from 1 review