Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Skin

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 42.9%Low 2 · 28.6%Moderate 2 · 28.6%High 0 · 0%

Topical antibiotics with steroids vs topical steroid

Global outcome (good or excellent improvement in symptoms or signs, or both) · people with eczema

Topical steroid plus topical antibiotic showed no clear difference in global outcome (good or excellent improvement in symptoms or signs,… compared with topical steroid (low certainty).

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
RR 1.1 [1, 1.21]
3 studies · 224 participants
Low

Topical antibiotics with steroids vs topical steroid

Change from baseline in quality of life IDQoL ranges from 0 to 30 with higher values indicating more impaired quality of life · people with eczema

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 42 participants
Moderate

Topical antibiotics with steroids vs topical steroid

Withdrawals due to adverse events · people with eczema

It is very uncertain whether topical steroid plus topical antibiotic changes adverse events requiring withdrawal from treatment compared with topical steroid (very low certainty).

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
RR 1.24 [0.21, 7.25]
4 studies · 325 participants
Very low

Topical antibiotics with steroids vs topical steroid

Minor adverse events not leading to withdrawal of treatment · people with eczema

It is very uncertain whether topical steroid plus topical antibiotic changes minor adverse events not requiring withdrawal from treatment compared with topical steroid (very low certainty).

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
RR 0.3 [0.12, 0.78]
2 studies · 218 participants
Very low

Topical antibiotics with steroids vs topical steroid

Microbiology Emergence of resistant organisms · people with eczema

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 65 participants
Very low

Topical antibiotics with steroids vs topical steroid

Global change in composite ratings scale EASI ranges from 0 to 72, objective SCORAD ranges from 0 to 83 and SCORAD ranges from 0 to 108, with higher values indicating greater severity. · people with eczema

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 256 participants
Low

Topical antibiotics with steroids vs topical steroid

No of participants in whom S. aureus was isolated · people with eczema

Topical steroid plus topical antibiotic probably leads to lower no of participants in whom S. aureus was isolated compared with topical steroid (moderate certainty).

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
RR 0.48 [0.27, 0.84]
7 studies · 298 participants
Moderate