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Evidence found and GRADE certainty

557 questions · 600 findings · 75 reviews

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No studies found 188 · 31.3%GRADE not reported 62 · 10.3%Very low 154 · 25.7%Low 122 · 20.3%Moderate 62 · 10.3%High 12 · 2%

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

Proportion of participants who required further glaucoma surgery, including laser · people with open‐angle glaucoma

Phacoemulsification + supraciliary microstent surgery showed no clear difference in proportion of participants who required further glaucoma surgeryat… compared with phacoemulsification alone (low certainty).

1 finding from 1 review

Vaginal POP surgery with concomitant continence procedure vs no concomitant continence procedure

Vaginal POP surgery with or without concomitant continence surgery: additional MUS vs vaginal repair alone · women with POP and occult SUI

Vaginal POP surgery with concomitant continence procedure probably leads to lower vaginal POP surgery with or without concomitant continence surgery:… compared with no concomitant continence procedure (moderate certainty).

1 finding from 1 review

Surgery vs preoperative pharmacological therapy and surgery

Adverse events · adults with growth‐hormone secreting pituitary adenomas

It is very uncertain whether surgery alone changes adverse events compared with preoperative pharmacological therapy and surgery (very low certainty).

1 finding from 1 review

Surgery vs preoperative pharmacological therapy and surgery

Non‐surgical therapy for recurrent or persistent diseaseRadiation therapy and/or pharmacologic therapy for recurrent or persistent disease · adults with growth‐hormone secreting pituitary adenomas

It is very uncertain whether surgery alone changes non‐surgical therapy for recurrent or persistent diseaseRadiation… compared with preoperative pharmacological therapy and surgery (very low certainty).

1 finding from 1 review

Early surgery vs late surgery

Complete recovery of facial nerve function at 12 months Defined as: complete recovery HB grade I. · Bell's palsy

It is very uncertain whether early surgery changes complete recovery of facial nerve function at 12 months Defined as:… compared with late surgery (very low certainty).

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

All‐cause mortality up to 30 days № of participants: 72 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes all‐cause mortality up to 30 days № of participants: 72 (1 RCT) compared with no prophylactic plasma transfusion before surgery/invasive… (very low certainty).

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

Major bleeding · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes major bleeding within 24 hours № of participants: 148 (2 RCTs) compared with no prophylactic plasma transfusion before surgery/invasive… (very low certainty).

1 finding from 1 review