Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

19 questions · 19 findings · 2 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 5 · 26.3%GRADE not reported 0 · 0%Very low 8 · 42.1%Low 3 · 15.8%Moderate 3 · 15.8%High 0 · 0%

Psychological interventions vs usual care

Adherence to inhaled therapies cMPR · children, adolescents or adults with CF

Summary of findings: psychological interventions probably leads to higher adherence to inhaled therapies: % of prescribed inhaled therapies… compared with usual care (moderate certainty).

1 finding from 1 review

Psychological interventions vs usual care

Treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) · children, adolescents or adults with CF

Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) compared with usual care (low certainty).

1 finding from 1 review

Psychological interventions vs usual care

Treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) · children, adolescents or adults with CF

Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) compared with usual care (low certainty).

1 finding from 1 review

Pregabalin vs placebo

Treatment‐related adverse effects · adults and children with sickle cell disease experiencing neuropathic pain

It is very uncertain whether summary of findings ‐ Pharmacological intervention (pregabalin) changes treatment‐related adverse effects compared with placebo (very low certainty).

1 finding from 1 review