Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

607 questions · 641 findings · 77 reviews

No studies found 114 · 17.8%GRADE not reported 25 · 3.9%Very low 170 · 26.5%Low 175 · 27.3%Moderate 123 · 19.2%High 34 · 5.3%

Inhaled steroids vs systemic steroids

Death or bronchopulmonary dysplasia at 36 weeks PMA · Neonates with developing BPD

Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age compared with systemic steroids (moderate certainty).

2 findings from 1 review

Inhaled steroids vs systemic steroids

Diastolic blood pressure > 95th percentile at 7 years · Neonates with developing BPD

Inhaled steroids probably leads to lower diastolic blood pressure > 95th percentile at 7 years compared with systemic steroids (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic steroids

General conceptual ability (GCA) score at 7 years The test has a standardisation mean of 100 and SD of 15 · Neonates with developing BPD

Inhaled steroids showed no clear difference in general conceptual ability (GCA) score at 7 years The test has a… compared with systemic steroids (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic steroids

Systolic blood pressure > 95th percentile at 7 years · Neonates with developing BPD

Inhaled steroids showed no clear difference in systolic blood pressure > 95th percentile at 7 years compared with systemic steroids (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic corticosteroids

BPD or death at 36 weeks' postmenstrual age№ of participants: 0 (0 RCTs) · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age among all randomised compared with systemic corticosteroids (moderate certainty).

1 finding from 1 review