Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

109 questions · 110 findings · 14 reviews

No studies found 16 · 14.5%GRADE not reported 16 · 14.5%Very low 25 · 22.7%Low 16 · 14.5%Moderate 25 · 22.7%High 12 · 10.9%

Statins vs placebo

Incidence of dementia · older people with normal cognitiona

Statins showed no clear difference in incidence of dementia Range of scale yes/no compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

Cognitive function · older people with normal cognitiona

Statins showed no clear difference in mini Mental State Examination Score Score out of 30 (higher score… compared with placebo (high certainty).

1 finding from 1 review

Statins vs placebo

Stroop Colour Word Test Total number of seconds required to complete the third Stroop card containing 40 items Measures attention · older people with normal cognitiona

Statins showed no clear difference in stroop Colour Word Test Total number of seconds required to complete… compared with placebo (high certainty).

1 finding from 1 review

Statins vs placebo

Picture‐Word Learning Test 15 Picture Learning Test Measures immediate and delayed recall · older people with normal cognitiona

Statins showed no clear difference in picture‐Word Learning Test 15 Picture Learning Test Measures… compared with placebo (high certainty).

1 finding from 1 review

Statins vs placebo

Letter Digit Coding Test Total number of correct entries completed in 60 seconds Measures processing speed · older people with normal cognitiona

Statins showed no clear difference in letter Digit Coding Test Total number of correct entries completed… compared with placebo (high certainty).

1 finding from 1 review

Statins vs placebo

Mean Modified Telephone Interview for Cognitive Status Score Score out of 39 · older people with normal cognitiona

Statins showed no clear difference in mean Modified Telephone Interview for Cognitive Status Score Score… compared with placebo (high certainty).

1 finding from 1 review

Statins vs placebo

Discontinuation of medication due to adverse events · older people with normal cognitiona

Statins showed no clear difference in adverse events leading to discontinuation of therapy compared with placebo (high certainty).

1 finding from 1 review

Statins vs Control at 4 months (3 ‐ 6 months)

Combined outcome of non‐fatal myocardial infarction, non‐fatal stroke, and total number of deaths · patients with acute coronary syndrome

Statins showed no clear difference in combined outcome of non‐fatal myocardial infarction, non‐fatal… compared with control at 4 months (3 to 6 months) (moderate certainty).

1 finding from 1 review

Statins vs Control at 4 months (3 ‐ 6 months)

Fatal & Nonfatal myocardial infarction or reinfarction · patients with acute coronary syndrome

Statins showed no clear difference in fatal and non‐fatal myocardial infarction or reinfarction compared with control at 4 months (3 to 6 months) (moderate certainty).

1 finding from 1 review