Findings

What do systematic reviews say?

28 questions · 28 findings · 4 reviews · Headline outcomes only

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No studies found 9 · 32.1%GRADE not reported 1 · 3.6%Very low 1 · 3.6%Low 7 · 25%Moderate 0 · 0%High 10 · 35.7%

Selenium vs placebo

Change in selenium concentrations (µg/L) · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 527 participants
Low

Selenium vs placebo

Incidence: lung cancer · healthy men

Selenium showed no clear difference in incidence: lung cancer compared with placebo (high certainty).

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
RR 1.11 [0.8, 1.54]
1 study · 17448 participants
High

Selenium vs placebo

Mortality: lung cancer · healthy men

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
1.09 [0.72, 1.66]
1 study · 17448 participants
High

Selenium vs placebo

Alopecia · healthy men

Selenium leads to higher adverse events: alopecia compared with placebo (high certainty).

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
RR 1.28 [1.07, 1.53]
1 study · 17448 participants
High

Selenium vs placebo

adverse events: grade 1 to 2 dermatitis · healthy men

Selenium leads to higher adverse events: grade 1 to 2 dermatitis compared with placebo (high certainty).

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
RR 1.16 [1.04, 1.31]
1 study · 17448 participants
High

Selenium vs placebo

Incidence: all cancers · healthy men

Selenium showed no clear difference in incidence: all cancers compared with placebo (high certainty).

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
RR 1.01 [0.92, 1.11]
1 study · 17448 participants
High

Selenium vs placebo

Mortality: all cancers · healthy men

Selenium showed no clear difference in mortality: all cancers compared with placebo (high certainty).

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
RR 1.02 [0.8, 1.3]
1 study · 17448 participants
High

Selenium vs placebo

Mortality: all causes · healthy men

Selenium showed no clear difference in mortality: all causes compared with placebo (high certainty).

1 finding from 1 review

Drugs for preventing lung cancer in healthy people 2020 · Cochrane Headline outcomes only
RR 0.98 [0.86, 1.13]
1 study · 17448 participants
High

Selenium vs placebo

All‐cause mortality · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Selenium vs placebo

Hospital admissions · adults with HIV infection

It is very uncertain whether selenium changes hospital admissions compared with placebo (very low certainty).

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
RR 0.4 [0.21, 0.75]
1 study · 186 participants
Very low

Selenium vs placebo

Change in CD4 count · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1187 participants
Low

Selenium vs placebo

Change in viral load · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 439 participants
Low

Selenium (+LT4) vs placebo (+LT4)

Change from baseline in health‐related quality of life · participants with Hashimoto's thyroiditis.

The review found no eligible studies for this question.

1 finding from 1 review

Selenium supplementation for Hashimoto's thyroiditis 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Selenium (+LT4) vs placebo (+LT4)

Change from baseline in assessment of symptoms such as mood, fatigue and muscle weakness Short‐Form Health Survey · participants with Hashimoto's thyroiditis.

Selenium (+LT4) may leads to higher change from baseline in assessment of symptoms such as mood, fatigue… compared with placebo (+LT4) (low certainty).

1 finding from 1 review

Selenium supplementation for Hashimoto's thyroiditis 2013 · Cochrane Headline outcomes only
RR 4.67 [1.61, 13.5]
1 study · 36 participants
Low

Selenium (+LT4) vs placebo (+LT4)

Adverse events post‐intervention Number of people reporting an adverse event before completing the intervention · participants with Hashimoto's thyroiditis.

Selenium (+LT4) showed no clear difference in proportion of participants reporting an adverse event compared with placebo (+LT4) (low certainty).

1 finding from 1 review

Selenium supplementation for Hashimoto's thyroiditis 2013 · Cochrane Headline outcomes only
RR 2.71 [0.29, 25.66]
3 studies · 258 participants
Low

Selenium (+LT4) vs placebo (+LT4)

Change from baseline in serum levels of anti‐thyroid peroxidase antibodies Decrease from 1508 to 25 IU/L · participants with Hashimoto's thyroiditis.

1 finding from 1 review

Selenium supplementation for Hashimoto's thyroiditis 2013 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 252 participants
Low

Selenium (+LT4) vs placebo (+LT4)

Change from baseline in LT4 replacement dosage at end of study · participants with Hashimoto's thyroiditis.

The review found no eligible studies for this question.

1 finding from 1 review

Selenium supplementation for Hashimoto's thyroiditis 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Selenium (+LT4) vs placebo (+LT4)

Costs · participants with Hashimoto's thyroiditis.

The review found no eligible studies for this question.

1 finding from 1 review

Selenium supplementation for Hashimoto's thyroiditis 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Selenium vs no intervention

Mean GI symptom scores · Women undergoing RT for gynecological cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Selenium vs no intervention

Acute and late GI toxicity (grade 2+) · Women undergoing RT for gynecological cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found