Progression to visual loss (loss of 3 or more lines on logMAR chart) · people with neovascular AMD
Radiotherapy showed no clear difference in loss of 3 or more lines of best‐corrected visual acuity Measured… compared with control (low certainty).
1 finding from 1 review
RR 0.82 [0.64, 1.04]
Studies not reported
Low
Change in visual acuity (logMAR) ‐ 12 months (negative is better) · people with neovascular AMD
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Contrast sensitivity (log contrast threshold) Measured using a Pelli‐Robson chart. Higher scores represent better contrast sensitivity. · people with neovascular AMD
1 finding from 1 review
no estimate extracted
Studies not reported
Low
New vessel growth Measured using fluorescein angiography or fundus photographs · people with neovascular AMD
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Quality of life · people with neovascular AMD
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Any adverse outcome · people with neovascular AMD
Radiotherapy may leads to lower any adverse outcome compared with control (low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Number of anti‐VEGF injections · people with neovascular AMD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Overall survival · nonmetastatic esophageal cancer
Chemoradiotherapy showed no clear difference in overall survival compared with chemoradiotherapy plus surgery (high certainty).
1 finding from 1 review
Freedom from locoregional relapse · nonmetastatic esophageal cancer
Chemoradiotherapy probably leads to lower freedom from locoregional relapse compared with chemoradiotherapy plus surgery (moderate certainty).
1 finding from 1 review
Quality of life · nonmetastatic esophageal cancer
1 finding from 1 review
Treatment‐related mortality · nonmetastatic esophageal cancer
Chemoradiotherapy may leads to higher treatment‐related mortality compared with chemoradiotherapy plus surgery (low certainty).
1 finding from 1 review
Use of salvage procedures for dysphagia · nonmetastatic esophageal cancer
Chemoradiotherapy may leads to lower use of salvage procedures for dysphagia compared with chemoradiotherapy plus surgery (low certainty).
1 finding from 1 review
Participant‐reported improvement in sialorrhea in the short term · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis
1 finding from 1 review
Reduction in the amount of saliva production in the short term using an objective measure · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events, reported as "negative experiences" · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis
It is very uncertain whether radiotherapy changes adverse events, reported as "negative experiences" compared with botulinum toxin (very low certainty).
1 finding from 1 review
Recurrence · adults with basal cell carcinoma of the skin
Radiotherapy may leads to higher recurrence at 3 years compared with surgical excision (with or without frozen section margin control) (low certainty).
2 findings from 1 review
Cosmetic outcome (good/excellent) · adults with basal cell carcinoma of the skin
Radiotherapy probably leads to lower cosmetic outcome (good/excellent) compared with surgical excision (with or without frozen section margin control) (moderate certainty).
1 finding from 1 review
Pain · adults with basal cell carcinoma of the skin
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Early treatment failure · adults with basal cell carcinoma of the skin
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found