Prokinetic vs placebo
It is very uncertain whether prokinetic changes not symptom‐free or no symptom improvement compared with placebo (very low certainty).
- RR 0.81 [0.74, 0.89]29 studies · 10044 participantsVery low
It is very uncertain whether prokinetic changes not symptom‐free or no symptom improvement compared with placebo (very low certainty).
It is very uncertain whether prokinetic changes adverse events compared with placebo (very low certainty).
It is very uncertain whether other prokinetics changes not symptom‐free or no symptoms improvement (itopride 50 three times… compared with domperidone 10mg three times a day (very low certainty).
It is very uncertain whether other prokinetics changes adverse events compared with domperidone 10mg three times a day (very low certainty).
Proton pump inhibitors plus prokinetics showed no clear difference in global symptoms of dyspepsia compared with prokinetics alone (moderate certainty).
Proton pump inhibitors plus prokinetics probably leads to lower adverse events compared with prokinetics alone (moderate certainty).