Cochrane · systematic review · CD009431
Prokinetics for functional dyspepsia
Pittayanon, R, Yuan, Y, Bollegala, NP, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 8 · 88.9%Low 1 · 11.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Prokinetic compared to placebo for functional dyspepsia
Population: functional dyspepsia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Not symptom‐free or no symptom improvement Prokinetic vs placebo | RR 0.81 [0.74, 0.89] | 29 studies · 10044 participants | Very low Downgraded: risk of bias |
Post‐treatment symptoms scores Prokinetic vs placebo | no estimate extracted | 6 studies · 2914 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Mean difference symptoms scores Prokinetic vs placebo | no estimate extracted | 11 studies · 1822 participants | Very low Downgraded: risk of bias |
Change of QoL scores Prokinetic vs placebo | no estimate extracted | 5 studies · 1774 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Adverse events Prokinetic vs placebo | RR 1.09 [0.95, 1.25] | 17 studies · 3811 participants | Very low Downgraded: risk of bias |
Other prokinetics compared to domperidone 10mg three times a day for functional dyspepsia
Population: functional dyspepsia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Not symptom‐free or no symptoms improvement (itopride 50 three times per day, cinitapride 1 mg three times per day, mosapride 5 mg three times per day versus domperidone 10 mg three times per day) Other prokinetics vs domperidone 10mg three times a day | RR 0.94 [0.83, 1.07] | 7 studies · 1527 participants | Very low Downgraded: risk of bias |
Post‐treatment scores Other prokinetics vs domperidone 10mg three times a day | no estimate extracted | 3 studies · 617 participants | Very low Downgraded: risk of bias |
Mean difference symptoms scores Other prokinetics vs domperidone 10mg three times a day | no estimate extracted | 4 studies · 839 participants | Very low Downgraded: risk of bias |
Adverse events Other prokinetics vs domperidone 10mg three times a day | RR 0.69 [0.5, 0.97] | 7 studies · 1557 participants | Very low Downgraded: risk of bias |