Findings

What do systematic reviews say?

27 questions · 28 findings · 2 reviews

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No studies found 3 · 10.7%GRADE not reported 2 · 7.1%Very low 0 · 0%Low 8 · 28.6%Moderate 9 · 32.1%High 6 · 21.4%

Pregabalin 300 mg or 600 mg vs placebo

mg pregabalin · adults with moderate or severe neuropathic pain

2 findings from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
300 participants
GRADE not reported
Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
600 participants
GRADE not reported

Pregabalin 300 mg vs placebo

Participant‐reported pain relief of 30% or greater · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 589 participants
Moderate

Pregabalin 300 mg vs placebo

Participant‐reported pain relief of 30% or greater · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 2320 participants
Moderate

Pregabalin 300 mg vs placebo

Participant‐reported pain relief of 50% or greater · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 2931 participants
Moderate

Pregabalin 300 mg vs placebo

Patient Global Impression of Change much or very much improved · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1050 participants
Moderate

Pregabalin 300 mg vs placebo

PGIC very much improved · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 501 participants
Low

Pregabalin 300 mg vs placebo

Lack of efficacy withdrawal · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 2430 participants
High

Pregabalin 300 mg vs placebo

Participant‐reported pain relief of 50% or greater · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 713 participants
Moderate

Pregabalin 300 mg vs placebo

Somnolence · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 3315 participants
Moderate

Pregabalin 300 mg vs placebo

Dizziness · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 3315 participants
Moderate

Pregabalin 300 mg vs placebo

Withdrawals due to adverse events · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 3384 participants
High

Pregabalin 300 mg vs placebo

Patient Global Impression of Change much or very much improved · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 568 participants
Low

Pregabalin 300 mg vs placebo

Lack of efficacy withdrawal · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 933 participants
High

Pregabalin 300 mg vs placebo

Somnolence · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 933 participants
Moderate

Pregabalin 300 mg vs placebo

Dizziness · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 933 participants
Moderate

Pregabalin 300 mg vs placebo

Withdrawals due to adverse events · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 933 participants
High

Pregabalin 300 mg or 600 mg vs placebo

Risk for at least one adverse event per patient · adults with moderate or severe neuropathic pain

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 3697 participants
High

Pregabalin 300 mg or 600 mg vs placebo

Serious AE · adults with moderate or severe neuropathic pain

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
17 studies · 4112 participants
High

Pregabalin 300 mg vs placebo

Pain score · women having medical abortion before 14 weeks' gestation

1 finding from 1 review

Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 107 participants
Low

Pregabalin 300 mg vs placebo

Nausea · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Pregabalin 300 mg showed no clear difference in gastrointestinal side effects (nausea) compared with placebo (low certainty).

1 finding from 1 review

Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
OR 0.85 [0.33, 2.19]
1 study · 107 participants
Low