Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

57 questions · 64 findings · 7 reviews

No studies found 11 · 17.2%GRADE not reported 5 · 7.8%Very low 29 · 45.3%Low 14 · 21.9%Moderate 2 · 3.1%High 3 · 4.7%

Pharmacological interventions vs placebo

Incidence of depression ‐ short‐term: < 6 months · adults with long‐term physical conditions (18 years or older)

It is very uncertain whether pharmacological interventions changes incidence of depression ‐ short‐term: < 6 months compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Incidence of depression ‐ medium term: 6‐12 months · adults with long‐term physical conditions (18 years or older)

It is very uncertain whether pharmacological interventions changes incidence of depression ‐ medium‐term: 6‐12 months compared with placebo (very low certainty).

1 finding from 1 review

Antidepressants vs placebo

Depression: meeting study criteria for depression at end of · people with stroke

It is very uncertain whether pharmacological interventions (antidepressants) changes depression: meeting study criteria for depression at end treatment… compared with placebo (very low certainty).

1 finding from 1 review

Antidepressants vs placebo

Adverse events: death ‐ at end of treatment (Analysis 1.14) · people with stroke

It is very uncertain whether pharmacological interventions (antidepressants) changes adverse events: death ‐ at end of treatment Analysis 1.12 compared with placebo (very low certainty).

1 finding from 1 review

Non‐pharmacological interventions for fear of childbirth (tocophobia) vs usual care

Birth preferences: prefer caesarean section · women with fear of childbirth (tocophobia)

Non‐pharmacological interventions for fear of childbirth (tocophobia) showed no clear difference in birth preferences: prefer caesarean section compared with usual care (low certainty).

1 finding from 1 review

Non‐pharmacological interventions for fear of childbirth (tocophobia) vs usual care

Epidural analgesia during labour · women with fear of childbirth (tocophobia)

Non‐pharmacological interventions for fear of childbirth (tocophobia) showed no clear difference in epidural analgesia during labour compared with usual care (low certainty).

1 finding from 1 review