Findings

What do systematic reviews say?

2 questions · 4 findings · 2 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 2 · 50%Moderate 0 · 0%High 0 · 0%

New‐generation antidepressants vs placebo

Repetition of SH at last · adults who engage in SH

Newer generation antidepressants showed no clear difference in repetition of SH at last compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for self‐harm in adults 2015 · Cochrane Headline outcomes only
OR 0.76 [0.42, 1.36]
3 studies · 243 participants
Low

New‐generation antidepressants vs placebo

Repetition of SH at post‐intervention · self‐harm in adults

It is very uncertain whether newer generation antidepressants (NGAs) changes repetition of SH by post‐intervention (NGA class)№ of participants:… compared with placebo (very low certainty).

3 findings from 1 review

Pharmacological interventions for self‐harm in adults 2021 · Cochrane Headline outcomes only
OR 0.59 [0.29, 1.19]
Studies not reported
Very low
Pharmacological interventions for self‐harm in adults 2021 · Cochrane Headline outcomes only
OR 0.67 [0.18, 2.41]
Studies not reported
Very low
Pharmacological interventions for self‐harm in adults 2021 · Cochrane Headline outcomes only
OR 0.55 [0.24, 1.29]
Studies not reported
Low