Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

38 questions · 40 findings · 4 reviews · Headline outcomes only

No studies found 10 · 25%GRADE not reported 1 · 2.5%Very low 18 · 45%Low 9 · 22.5%Moderate 0 · 0%High 2 · 5%

NSAIDs vs paracetamol

All adverse effects ‐ ibuprofen versus paracetamol · women with primary dysmenorrhoea

It is very uncertain whether NSAIDs changes all adverse effects ‐ ibuprofen versus paracetamol compared with paracetamol (very low certainty).

1 finding from 1 review

NSAIDs vs combination (paracetamol and opioid) analgesic

Little or no pain at 1 to 3 days · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes little or no pain at 1 to 3 days compared with combination (paracetamol and opioid) analgesic (very low certainty).

2 findings from 1 review

NSAIDs vs combination (paracetamol and opioid) analgesic

Return to function on day 7 or later Assessed as 'cure' · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes return to function on day 7 or later Assessed as 'cure' compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review

NSAIDs vs combination (paracetamol and opioid) analgesic

Gastrointestinal adverse events · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes gastrointestinal adverse events compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review

NSAIDs vs combination (paracetamol and opioid) analgesic

Neurological adverse effects · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes neurological adverse events compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review

NSAIDs vs paracetamol

Return to function on day 7 or later (numbers returning to full function or returning to training) · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes return to function on day 7 or latere compared with paracetamol (very low certainty).

1 finding from 1 review