Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

95 questions · 99 findings · 12 reviews

No studies found 23 · 23.2%GRADE not reported 18 · 18.2%Very low 27 · 27.3%Low 24 · 24.2%Moderate 5 · 5.1%High 2 · 2%

NSAIDs vs placebo

Substantial benefit: At least 50% reduction in pain, or PGIC much improved · adults with fibromyalgia

It is very uncertain whether NSAID changes substantial pain relief: at least 50% reduction in pain, or PGIC… compared with placebo (very low certainty).

1 finding from 1 review

NSAIDs vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with fibromyalgia

It is very uncertain whether NSAID changes moderate pain relief: at least 30% reduction in pain, or PGIC much… compared with placebo (very low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Need for additional analgesia (4 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID (single administration, any dose) changes need for additional analgesia (4 hours after administration) compared with paracetamol (very low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Need for additional analgesia (6 hours after administration) · women with perineal pain in the early postpartum period

NSAID (single administration, any dose) may leads to lower need for additional analgesia (6 hours after administration) compared with paracetamol (low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Maternal drug adverse effects (6 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID (single administration, any dose) changes maternal drug adverse effects (6 hours after administration) compared with paracetamol (very low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Relief of pain · women with perineal pain in the early postpartum period

NSAID (single administration, any dose) may leads to higher adequate pain relief (4 hours after administration) compared with paracetamol (low certainty).

2 findings from 1 review