Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

50 questions · 56 findings · 5 reviews

No studies found 16 · 28.6%GRADE not reported 3 · 5.4%Very low 20 · 35.7%Low 12 · 21.4%Moderate 3 · 5.4%High 2 · 3.6%

NSAID (systemic) vs paracetamol

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

NSAID (systemic) showed no clear difference in pain intensity (VAS 0-100 mm) compared with paracetamol (low certainty).

3 findings from 1 review

NSAID (single administration, any dose) vs paracetamol

Need for additional analgesia (4 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID (single administration, any dose) changes need for additional analgesia (4 hours after administration) compared with paracetamol (very low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Need for additional analgesia (6 hours after administration) · women with perineal pain in the early postpartum period

NSAID (single administration, any dose) may leads to lower need for additional analgesia (6 hours after administration) compared with paracetamol (low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Maternal drug adverse effects (6 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID (single administration, any dose) changes maternal drug adverse effects (6 hours after administration) compared with paracetamol (very low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Relief of pain · women with perineal pain in the early postpartum period

NSAID (single administration, any dose) may leads to higher adequate pain relief (4 hours after administration) compared with paracetamol (low certainty).

2 findings from 1 review