Findings

What do systematic reviews say?

24 questions · 32 findings · 3 reviews · Pain, Palliative and Supportive Care

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No studies found 2 · 6.3%GRADE not reported 0 · 0%Very low 12 · 37.5%Low 14 · 43.8%Moderate 4 · 12.5%High 0 · 0%

Morphine vs placebo

Reported outcomes approximating to 30% reduction in pain · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
62 participants
Very low

Morphine vs placebo

At least 50% reduction in pain · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
62 participants
Very low

Morphine vs placebo

Patient Global Impression of Change much or very much improved · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Very low

Morphine vs placebo

Any pain‐related outcome (moderate pain improvement) · adults with neuropathic pain

It is very uncertain whether morphine changes any pain‐related outcome (moderate pain improvement) compared with placebo (very low certainty).

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
RD 0.27 [0.16, 0.38]
4 studies · 263 participants
Very low

Morphine vs placebo

Serious adverse events · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 289 participants
Very low

Morphine vs placebo

Death · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 289 participants
Very low

Morphine vs placebo

Any adverse event · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 289 participants
Very low

Morphine vs placebo

Withdrawal (all‐cause) · adults with neuropathic pain

It is very uncertain whether morphine changes all‐cause withdrawal compared with placebo (very low certainty).

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
RD 0.04
4 studies · 289 participants
Very low

Morphine vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients undergoing knee arthroscopy

3 findings from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 297 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 297 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 297 participants
Low

Morphine vs bupivacaine

Adverse eventsPercentage of participants with any adverse event · patients undergoing knee arthroscopy

Morphine showed no clear difference in adverse eventsPercentage of participants with any adverse event compared with bupivacaine (moderate certainty).

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
RR 0.68 [0.09, 5.17]
4 studies · 210 participants
Moderate

Morphine vs NSAIDs

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients undergoing knee arthroscopy

3 findings from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 80 participants
Very low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 80 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 80 participants
Low

Morphine vs NSAIDs

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · patients undergoing knee arthroscopy

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Morphine vs NSAIDs

Adverse eventsPercentage of participants with any adverse event · patients undergoing knee arthroscopy

Morphine showed no clear difference in adverse eventsPercentage of participants with any adverse event compared with NSAIDs (moderate certainty).

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
RR 0.75 [0.19, 3.04]
3 studies · 120 participants
Moderate

Morphine vs placebo

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · patients undergoing knee arthroscopy

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 124 participants
Low

Morphine vs placebo

Adverse eventsPercentage of participants with any adverse event · patients undergoing knee arthroscopy

Morphine showed no clear difference in adverse eventsPercentage of participants with any adverse event compared with placebo (low certainty).

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
RR 1.09 [0.51, 2.36]
8 studies · 314 participants
Low

Morphine vs bupivacaine

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients undergoing knee arthroscopy

3 findings from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 248 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 330 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 270 participants
Low

Morphine vs bupivacaine

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · patients undergoing knee arthroscopy

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 162 participants
Moderate

IA morphine vs IM morphine

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients undergoing knee arthroscopy

3 findings from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Very low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 39 participants
Low

IA morphine vs IM morphine

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · patients undergoing knee arthroscopy

The review found no eligible studies for this question.

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

IA morphine vs IM morphine

Adverse eventsPercentage of participants with any adverse event · patients undergoing knee arthroscopy

The review found no eligible studies for this question.

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found