What do systematic reviews say?

3 questions · 3 findings · 3 reviews · Pregnancy and Childbirth

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 1 · 33.3%Moderate 0 · 0%High 1 · 33.3%

Metformin vs glibenclamide ‐ neonatal outcomes

Large‐for‐gestational age · Infants of women diagnosed with gestational diabetes

Metformin showed no clear difference in large‐for‐gestational age compared with glibenclamide ‐ neonatal outcomes (low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies for the treatment of women with gestational diabetes 2017 · Cochrane Headline outcomes only
RR 0.67 [0.24, 1.83]
2 studies · 246 participants
Low

Metformin vs placebo

Large‐for‐gestational age · women with obesity during pregnancy

Metformin showed no clear difference in large‐for‐gestational‐age infant, defined as birthweight ≥ 90th… compared with placebo (high certainty).

1 finding from 1 review

Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes 2018 · Cochrane Headline outcomes only
RR 0.95 [0.7, 1.3]
2 studies · 831 participants
High

Metformin vs insulin

Large‐for‐gestational age · women with type 2 diabetes

It is very uncertain whether infant outcomes: oral anti‐diabetic agent (metformin) changes large‐for‐gestational age compared with insulin (very low certainty).

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
RR 1.12 [0.73, 1.72]
1 study · 206 participants
Very low