Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

360 questions · 397 findings · 57 reviews

No studies found 74 · 18.6%GRADE not reported 83 · 20.9%Very low 66 · 16.6%Low 88 · 22.2%Moderate 62 · 15.6%High 24 · 6%

LipiFlow vs basic warm compresses

Mean change from baseline in meibomian gland expression scores at 1 to 4 weeks (higher is favored) · people with dry eye

It is very uncertain whether lipiFlow changes mean change from baseline in meibomian gland expression scores at 1… compared with basic warm compresses (very low certainty).

1 finding from 1 review

LipiFlow vs basic warm compresses

Mean change from baseline in meibum quality scores at 1 to 4 weeks (higher is favored) · people with dry eye

It is very uncertain whether lipiFlow changes mean change from baseline in meibum quality scores at 1 to 4 weeks… compared with basic warm compresses (very low certainty).

1 finding from 1 review

LipiFlow vs thermostatic devices

Mean change from baseline in meibomian gland expression scores at 1 to 4 weeks (higher is favored) · people with dry eye

LipiFlow showed no clear difference in mean change from baseline in meibomian gland expression scores at 1… compared with thermostatic devices (low certainty).

1 finding from 1 review

LipiFlow vs thermostatic devices

Mean change from baseline in meibum quality scores at 1 to 4 weeks (higher is favored) · people with dry eye

LipiFlow showed no clear difference in mean change from baseline in meibum quality scores at 1 to 4 weeks… compared with thermostatic devices (low certainty).

1 finding from 1 review

Anticipated low‐responders: higher vs lower dose of FSH

300/450 IU vs 150 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure

Anticipated low responders: higher showed no clear difference in 300/450 IU vs 150 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Anticipated low‐responders: higher vs lower dose of FSH

400/450 IU vs 300 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure

Anticipated low responders: higher showed no clear difference in 400/450 IU vs 300 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Anticipated low‐responders: higher vs lower dose of FSH

IU vs 450 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure

Anticipated low responders: higher showed no clear difference in IU vs 450 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Clobazam (low, medium and high doses) plus ASMs vs placebo plus ASMs

Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age

Clobazam (low, medium and high doses) plus ASMs leads to higher number of participants with adverse events leading to study… compared with placebo plus ASMs (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Myocardial infarction · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in myocardial infarction compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Stroke · people with or without existing cardiovascular disease, men and women

It is very uncertain whether homocysteine‐lowering interventions (high dose) changes stroke compared with homocysteine‐lowering interventions (low dose) (very low certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in death by any cause compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

High maternal allostatic load (chronic stress) and low socioeconomic status vs Lower maternal allostatic load

Dental caries in children · Mother-child pairs

In one cross-sectional study, higher maternal allostatic load was associated with child dental caries experience and with health-related maternal care-taking behaviours; not pooled (ungraded).

1 finding from 1 review

ULTRA LOW DOSE (<2 mg/day) vs ANY DOSE ‐ short term

Leaving the study early · patients with schizophrenia

ULTRA LOW DOSE (<2 mg/day) showed no clear difference in leaving the study early: Any reason ‐ when compared with… compared with ANY DOSE ‐ short term (moderate certainty).

1 finding from 1 review

ULTRA LOW DOSE (<2 mg/day) vs ANY DOSE ‐ short term

Leaving the study early: any reason ‐ when compared with high dose ( greater than or equal to 10 mg) · patients with schizophrenia

ULTRA LOW DOSE (<2 mg/day) showed no clear difference in leaving the study early: Any reason ‐ when compared with high dose… compared with ANY DOSE ‐ short term (moderate certainty).

1 finding from 1 review