Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

360 questions · 397 findings · 57 reviews

No studies found 74 · 18.6%GRADE not reported 83 · 20.9%Very low 66 · 16.6%Low 88 · 22.2%Moderate 62 · 15.6%High 24 · 6%

Lower‐dose methylnaltrexone vs higher dose

Adverse events · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction

Methylnaltrexone lower dose showed no clear difference in adverse events compared with higher dose (low certainty).

1 finding from 1 review

Lower blood pressure targets vs standard blood pressure targets

Total serious adverse events · cardiovascular disease with high blood pressure

Lower blood pressure targets showed no clear difference in total serious adverse events compared with standard blood pressure targets (low certainty).

1 finding from 1 review

Lower blood pressure targets vs standard blood pressure targets

Cardiovascular mortality · cardiovascular disease with high blood pressure

Lower blood pressure targets showed no clear difference in cardiovascular mortality compared with standard blood pressure targets (moderate certainty).

1 finding from 1 review

Lower blood pressure targets vs standard blood pressure targets

Withdrawals due to adverse events · cardiovascular disease with high blood pressure

It is very uncertain whether lower blood pressure targets changes participant withdrawals due to adverse effects compared with standard blood pressure targets (very low certainty).

1 finding from 1 review