Seizure freedom · people with drug‐resistant generalised tonic‐clonic seizures
It is very uncertain whether add‐on lamotrigine changes seizure freedom (i.e. total cessation of seizure activity) compared with placebo (very low certainty).
1 finding from 1 review
Treatment withdrawal · people with drug‐resistant generalised tonic‐clonic seizures
It is very uncertain whether add‐on lamotrigine changes treatment withdrawal compared with placebo (very low certainty).
1 finding from 1 review
Adverse effects · people with drug‐resistant generalised tonic‐clonic seizures
It is very uncertain whether add‐on lamotrigine changes adverse effects compared with placebo (very low certainty).
1 finding from 1 review
At least 50% of maximum pain relief · neuropathic pain (three studies in painful diabetic neuropathy)
1 finding from 1 review
no estimate extracted
Studies not reported
High
Adverse events as N of participants with at least one adverse event objective · neuropathic pain (three studies in painful diabetic neuropathy)
1 finding from 1 review
no estimate extracted
Studies not reported
High
Participants with a serious adverse event (all conditions) · neuropathic pain (three studies in painful diabetic neuropathy)
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Rash · neuropathic pain (three studies in painful diabetic neuropathy)
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Deaths (all conditions) · neuropathic pain (three studies in painful diabetic neuropathy)
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Seizure freedom · Lennox‐Gastaut syndrome, any age
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Number of participants with ≥ 75% reduction in all seizures · Lennox‐Gastaut syndrome, any age
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
50% or greater reduction in seizure frequency · Lennox‐Gastaut syndrome, any age
Lamotrigine plus ASMs leads to higher number of participants with ≥ 50% median reduction in all seizures compared with placebo plus ASMs (high certainty).
1 finding from 1 review
Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age
Lamotrigine plus ASMs showed no clear difference in number of participants with adverse events leading to study… compared with placebo plus ASMs (low certainty).
1 finding from 1 review
50% or greater reduction in seizure frequency · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine probably leads to higher 50% or greater reduction in seizure frequency (ITT analysis) compared with placebo (moderate certainty).
1 finding from 1 review
Treatment withdrawal · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine showed no clear difference in treatment withdrawal compared with placebo (moderate certainty).
1 finding from 1 review
Ataxia · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine probably leads to higher ataxia compared with placebo (moderate certainty).
1 finding from 1 review
Dizziness · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine probably leads to higher dizziness compared with placebo (moderate certainty).
1 finding from 1 review
Fatigue · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine probably leads to lower fatigue compared with placebo (moderate certainty).
1 finding from 1 review
Nausea · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine probably leads to higher nausea compared with placebo (moderate certainty).
1 finding from 1 review
Diplopia · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine probably leads to higher diplopia compared with placebo (moderate certainty).
1 finding from 1 review
Time to treatment failure (any reason related to treatment) All participants Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…
Summary of findings: lamotrigine probably leads to lower time to treatment failure (any reason related to treatment) All… compared with carbamazepine (moderate certainty).
1 finding from 1 review