Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

23 questions · 24 findings · 7 reviews

No studies found 6 · 25%GRADE not reported 11 · 45.8%Very low 5 · 20.8%Low 2 · 8.3%Moderate 0 · 0%High 0 · 0%

Lactobacillus vs placebo

Episodes of confirmed vaginal candidiasis fungal smear · prevention and treatment of vulvovaginal candidiasis in women with HIV infection

Lactobacillus showed no clear difference in episodes of confirmed vaginal candidiasis fungal smear compared with placebo (low certainty).

1 finding from 1 review

Lactobacillus vs Clotrimazole 10 mg (partially absorbed)

Episodes of confirmed vaginal candidiasis fungal smear · prevention and treatment of vulvovaginal candidiasis in women with HIV infection

Lactobacillus showed no clear difference in episodes of confirmed vaginal candidiasis fungal smear compared with clotrimazole (low certainty).

1 finding from 1 review

Kefir ( Lactobacillus bacteria) vs no intervention

Pain intensity (measure on a 0‐3 four‐point scale) · people with inflammatory bowel disease
2 findings from 1 review

Lactobacillus-derived postbiotics vs Not specified

Streptococcus mutans growth and biofilm formation · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro

No meta-analysis was conducted; the narrative synthesis reported inhibition of Streptococcus mutans growth and biofilm formation.

1 finding from 1 review

Lactobacillus-derived postbiotics vs Not specified

Virulence-gene expression related to adhesion acid production and exopolysaccharide synthesis · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro

No meta-analysis was conducted; the narrative synthesis reported reduced expression of Streptococcus mutans virulence genes.

1 finding from 1 review

Lactobacillus brevis CD2 lozenges vs placebo control

OLT, VSC and breath print scores · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…
1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    Marchetti 2015 (2-arm RCT) compared Lactobacillus brevis CD2 lozenges versus placebo lozenges (OLT, VSC and breath print). The study did not report any usable data and hence could not be included in the meta-analysis.
    1 study
    GRADE not reported

Lactobacillus salivarius WB21 tablets vs placebo (3 tablets/4 times a day

OLT and VSC scores · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…
1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    Suzuki 2014 (cross-over RCT) compared Lactobacillus salivarius WB21 tablets versus placebo tablets (OLT and VSC by gas chromatography). The trial did not give usable data and we could not extract data from the graph.
    1 study
    GRADE not reported

Probiotic mouthwash (e.g., Lactobacillus-based) vs Blank control

Cariogenic bacteria (Mutans streptococci) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)

Probiotic mouthwash has inconsistent effects on Mutans streptococci colony counts versus blank control; the evidence is very uncertain (very low certainty).

1 finding from 1 review

Lactobacillus beta lactoperoxidase (LPO) tablets vs placebo (3 tablets/4 times a day

Volatile sulphur compounds (VSC), gas chromatography · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…
1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    Nakano 2017 (2-arm trial) compared Lactobacillus beta LPO tablets versus placebo tablets (VSC by OralChroma). The trial did not report any usable data and hence could not be included in the analysis.
    1 study
    GRADE not reported

Significant salivary microbial (Lactobacillus) load vs No/low significant microbial load

Dental caries · Primary school children in Ethiopia

A significant salivary microbial (Lactobacillus) load was associated with higher odds of dental caries (OR 3.82, 95% CI 3.439-4.192; ungraded).

1 finding from 1 review