Cochrane · systematic review · CD008739
Interventions for prevention and treatment of vulvovaginal candidiasis in women with HIV infection
Ray, A, Ray, S, George, AT, et al. · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
HIV/AIDSAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 28.6%Very low 1 · 7.1%Low 3 · 21.4%Moderate 6 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Interventions for prevention and treatment of vulvovaginal candidiasis in women with HIV infection
Population: prevention and treatment of vulvovaginal candidiasis in women with HIV infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cure | RR 0 [0, 0] | 0 studies · 1 participants | Ungraded |
Episode of confirmed vaginal candidiasis ‐ Upto 12 months Fungal smears | RR 0.68 [0.47, 0.97] | 1 study · 323 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Episode of confirmed vaginal candidiasis ‐ Upto 24 Months Fungal smears | RR 0.79 [0.63, 0.99] | 1 study · 323 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Emergence of non albicans species of Candida ‐ At 12 months Fungal Smears | RR 1.46 [0.85, 2.51] | 1 study · 323 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Emergence of non albicans species of Candida ‐ At 24 months Fungal Smears | RR 1.32 [0.89, 1.94] | 1 study · 323 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
In Vitro resistance to azoles ‐ Candida albicans MIC >= 64 micrograms/ml | RR 0.86 [0.15, 4.9] | 1 study · 96 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
In Vitro resistance to azoles ‐ Non albicans Candida MIC>= 64 micrograms/ml | RR 5.57 [1.7, 18.29] | 1 study · 96 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Lactobacillus compared to Clotrimazole for prevention and treatment of vulvovaginal candidiasis in women with HIV infection
Population: prevention and treatment of vulvovaginal candidiasis in women with HIV infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cure Lactobacillus vs Clotrimazole | RR 0 [0, 0] | 0 studies · 0 participants | Ungraded |
Episodes of confirmed vaginal candidiasis fungal smear Lactobacillus vs Clotrimazole | RR 1.11 [0.45, 2.76] | 1 study · 108 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Lactobacillus compared to Placebo for prevention and treatment of vulvovaginal candidiasis in women with HIV infection
Population: patients with prevention and treatment of vulvovaginal candidiasis in women with HIV infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cure Lactobacillus vs Placebo | RR 0 [0, 0] | 0 studies · 0 participants | Ungraded |
Episodes of confirmed vaginal candidiasis fungal smear Lactobacillus vs Placebo | RR 0.54 [0.26, 1.13] | 1 study · 114 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Clotrimazole compared to Placebo for prevention and treatment of vulvovaginal candidiasis in women with HIV infection
Population: patients with prevention and treatment of vulvovaginal candidiasis in women with HIV infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cure Clotrimazole vs Placebo | RR 0 [0, 0] | 0 studies · 0 participants | Ungraded |
Episode of confirmed vaginal candidiasis fungal smear Clotrimazole vs Placebo | RR 0.49 [0.22, 1.09] | 1 study · 106 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Azoles compared to Placebo for prevention and treatment of vulvovaginal candidiasis in women with HIV infection
Population: patients with prevention and treatment of vulvovaginal candidiasis in women with HIV infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Episode of confirmed vaginal candidiasis Fungal Smears Azoles vs Placebo | RR 0.63 [0.46, 0.88] | 2 studies · 429 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |