Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 16 findings · 3 reviews · Vascular

No studies found 2 · 12.5%GRADE not reported 0 · 0%Very low 5 · 31.3%Low 2 · 12.5%Moderate 7 · 43.8%High 0 · 0%

Low molecular weight heparin vs no LMWH

Incidence of compromised microcirculation requiring invasive intervention (re‐exploration) (analysed by digit, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin (LMWH) changes incidence of compromised microcirculation requiring invasive… compared with no LMWH (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs no LMWH

Incidence of compromised microcirculation requiring invasive intervention (incision) (analysed by digit, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin (LMWH) changes incidence of compromised microcirculation requiring invasive… compared with no LMWH (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs no LMWH

Microvascular insufficiency due to vessel occlusion ‐ arterial occlusion (analysed by digit, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin (LMWH) changes microvascular insufficiency due to vessel occlusion ‐ arterial… compared with no LMWH (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs no LMWH

Microvascular insufficiency due to vessel occlusion ‐ venous occlusion (analysed by digit, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin (LMWH) changes microvascular insufficiency due to vessel occlusion ‐ venous… compared with no LMWH (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs no LMWH

Success rate of replantation1 (analysed by digit, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin (LMWH) changes success rate of replantation1 (analysed by digit, compared with no LMWH (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs UFH

Incidence of recurrent VTE1 after initial treatment (up to 15 days) · patients with venous thromboembolism.

LMWH probably leads to lower incidence of recurrent VTE1 after initial treatment (up to 15 days) compared with UFH (moderate certainty).

1 finding from 1 review

Low molecular weight heparin vs UFH

Recurrent VTE · patients with venous thromboembolism.

LMWH probably leads to lower incidence of recurrent VTE1 (3 months compared with UFH (moderate certainty).

2 findings from 1 review

Low molecular weight heparin vs vitamin K antagonist (VKA)

Recurrent VTE · patients with symptomatic VTE requiring long term treatment (3 months) for symptomatic VTE

LMWH showed no clear difference in incidence of recurrent VTE (treatment duration 3 months) compared with VKA (moderate certainty).

1 finding from 1 review

Low molecular weight heparin vs vitamin K antagonist (VKA)

Major bleeding · patients with symptomatic VTE requiring long term treatment (3 months) for symptomatic VTE

LMWH may leads to lower incidence of major bleeding (treatment duration 3 months) compared with VKA (low certainty).

1 finding from 1 review

Low molecular weight heparin vs vitamin K antagonist (VKA)

Mortality (treatment duration 3 months) · patients with symptomatic VTE requiring long term treatment (3 months) for symptomatic VTE

LMWH showed no clear difference in mortality (treatment duration 3 months) compared with VKA (moderate certainty).

1 finding from 1 review