Findings

What do systematic reviews say?

32 questions · 32 findings · 4 reviews

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No studies found 4 · 12.5%GRADE not reported 1 · 3.1%Very low 12 · 37.5%Low 2 · 6.3%Moderate 5 · 15.6%High 8 · 25%

Dexketoprofen 20 mg or 25 mg vs placebo

Participants with ≥ 1 adverse event following a single dose · adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single dose oral ketoprofen or dexketoprofen for acute postoperative pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 536 participants
High

Dexketoprofen 20 mg or 25 mg vs placebo

Participants with a serious adverse event following a single dose · adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single dose oral ketoprofen or dexketoprofen for acute postoperative pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1271 participants
Very low

Dexketoprofen 25 mg plus tramadol 75 mg vs placebo

Participant‐reported pain relief of 50% or greater · adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 748 participants
Moderate

Dexketoprofen 25 mg plus tramadol 75 mg vs placebo

Median (mean) time to use of rescue medication · adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Moderate

Dexketoprofen 25 mg plus tramadol 75 mg vs placebo

Number of women requiring rescue medication · adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 123 participants
Very low

Dexketoprofen 25 mg plus tramadol 75 mg vs placebo

Participants with ≥ 1 adverse event following a single dose, and after 3 to 5 days · adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 123 participants
Very low

Dexketoprofen 25 mg plus tramadol 75 mg vs placebo

Participants with a serious adverse event following a single dose, and after 3 to 5 days · adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 123 participants
Very low

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

Time off school or work · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
The study did not report this outcome.
0 studies
No studies found

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

Failure to complete orthodontic treatment due to pain · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
The study did not report this outcome.
0 studies
No studies found

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
The study did not report this outcome.
0 studies
No studies found

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
4 days (not usable)
One study (Lauritano 2000) compared ketoprofen 160 mg with benzidamine chloride 22.5 mg mouthwashes; it presented data at 4 days only, so the data could not be used in this review; no GRADE rating.
1 study
GRADE not reported

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

Adverse events · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
The study did not report this outcome.
0 studies
No studies found