Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

19 questions · 19 findings · 3 reviews · Neonatal

No studies found 0 · 0%GRADE not reported 2 · 10.5%Very low 8 · 42.1%Low 4 · 21.1%Moderate 5 · 26.3%High 0 · 0%

Intravenous fluid supplementation vs no fluid supplementation

Proportion of infants who required exchange transfusion · newborn infants with unconjugated hyperbilirubinaemia undergoing phototherapy

Intravenous fluid supplementation may leads to lower proportion of infants who required exchange transfusion compared with no fluid supplementation (low certainty).

1 finding from 1 review

Intravenous immunoglobulin plus phototherapy vs phototherapy alone

Use of ET (≥ 1); placebo‐controlled studies · neonates with alloimmune hemolytic disease

Intravenous immunoglobulin plus phototherapy showed no clear difference in use of ET (≥ 1); placebo‐controlled studies compared with phototherapy alone (moderate certainty).

1 finding from 1 review

Intravenous immunoglobulin plus phototherapy vs phototherapy alone

Use of top‐up transfusion in 1st week of life; all studies · neonates with alloimmune hemolytic disease

Intravenous immunoglobulin plus phototherapy showed no clear difference in use of top‐up transfusion in 1st week of life; all studies compared with phototherapy alone (low certainty).

1 finding from 1 review

Intravenous immunoglobulin plus phototherapy vs phototherapy alone

Use of top‐up transfusion after 1st week of life; all studies · neonates with alloimmune hemolytic disease

It is very uncertain whether intravenous immunoglobulin plus phototherapy changes use of top‐up transfusion after 1st week of life; all studies compared with phototherapy alone (very low certainty).

1 finding from 1 review