Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

54 questions · 56 findings · 8 reviews · Airways

No studies found 12 · 21.4%GRADE not reported 1 · 1.8%Very low 27 · 48.2%Low 14 · 25%Moderate 2 · 3.6%High 0 · 0%

Intervention vs usual care

Exacerbations (number of people experiencing ≥ 1 exacerbations) · COPD and at least one other long‐term condition

It is very uncertain whether intervention changes exacerbations ‐ number of people experiencing one or more  compared with usual care (very low certainty).

1 finding from 1 review

Multi‐component intervention vs other treatments/routine care

Exacerbations (number of people experiencing ≥ 1 exacerbations) · the management of chronic obstructive pulmonary disease

It is very uncertain whether multi‐component intervention changes exacerbations: number of people experiencing at least one exacerbation compared with other intervention or routine, usual care or control treatment (very low certainty).

1 finding from 1 review

Multi‐component intervention vs other treatments/routine care

Number experiencing adverse effects · the management of chronic obstructive pulmonary disease

It is very uncertain whether multi‐component intervention changes adverse events: number of people experiencing an AE compared with other intervention or routine, usual care or control treatment (very low certainty).

1 finding from 1 review

Multi‐component intervention vs other treatments/routine care

Number of participants experiencing any serious adverse events · the management of chronic obstructive pulmonary disease

Multi‐component intervention showed no clear difference in adverse events: number of people experiencing a serious adverse event compared with other intervention or routine, usual care or control treatment (low certainty).

1 finding from 1 review

Multi‐component intervention vs control

Adverse events: number of people experiencing adverse events (all cause or COPD‐related), serious adverse events, mortality · COPD

Multi‐component intervention showed no clear difference in adverse events: number of people experiencing adverse events (all… compared with control (low certainty).

1 finding from 1 review