Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,024 questions · 3,338 findings · 330 reviews

No studies found 735 · 22%GRADE not reported 282 · 8.4%Very low 962 · 28.8%Low 870 · 26.1%Moderate 384 · 11.5%High 105 · 3.1%

Lifestyle interventions vs control ‐ Maternal outcomes

Hypertensive disorders of pregnancy: pre‐eclampsia · women with gestational diabetes mellitus

Lifestyle interventions showed no clear difference in hypertensive disorders of pregnancy (pre‐eclampsia) compared with control ‐ Maternal outcomes (low certainty).

1 finding from 1 review

Lifestyle interventions vs control ‐ Maternal outcomes

Postnatal weight retention or return to pre‐pregnancy weight · women with gestational diabetes mellitus

Lifestyle interventions may leads to higher postnatal weight retention or return to pre‐pregnancy weight compared with control ‐ Maternal outcomes (low certainty).

1 finding from 1 review

Workplace interventions vs usual care

Depression (6 months or more) MADRS measured 6 months after intervention (Aljumah 2015). PHQ‐9 measured 6 months after intervention (LeBlanc 2015). QIDS‐J measured 6 months after intervention (Aoki 2019a). Hospital Anxiety and Depression Scale (HA... · workers on sick leave
1 finding from 1 review

Parenting interventions vs usual care

Medically attended or self‐reported injuries ‐ RCTs only · parents of children between the ages of 0 and 18 years

Parenting interventions probably leads to lower medically attended or self‐reported injuries ‐ RCTs only compared with usual care (moderate certainty).

1 finding from 1 review

Pharmacological interventions vs pharmacological intervention

Adverse events ‐ Metformin plus liraglutide vs metformin Nausea Diarrhoea Headache · obese women with subfertility

It is very uncertain whether pharmacological intervention changes adverse events ‐ Metformin plus liraglutide vs metformin Nausea… compared with pharmacological intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions vs pharmacological intervention

Clinical pregnancyMetformin plus liraglutide vs metformin Met + CC + L‐carnitine vs Met + CC + placebo · obese women with subfertility

It is very uncertain whether pharmacological intervention changes clinical pregnancyMetformin plus liraglutide vs metformin Met + CC +… compared with pharmacological intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions vs pharmacological intervention

MiscarriageMet + CC + L‐carnitine vs Met + CC + placebo · obese women with subfertility

It is very uncertain whether pharmacological intervention changes miscarriageMet + CC + L‐carnitine vs Met + CC + placebo compared with pharmacological intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions vs pharmacological intervention

Weight ‐ BMI changeMetformin plus liraglutide vs metformin Met + CC + L‐carnitine vs Met + CC + placebo Weight changeDexfenfluramine vs placebo Weight ‐ body fatMetformin plus liraglutide vs metformin · obese women with subfertility
1 finding from 1 review