What do systematic reviews say?

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality at day 30 compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.88 [0.81, 1.1]
  5 studies · 2402 participants
  Low

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality: patients with sepsis compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.94 [0.69, 1.27]
  5 studies · 966 participants
  Low

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality: patients without sepsis compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.89 [0.69, 1.15]
  4 studies · 1216 participants
  Low

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality after 30 days post‐randomisation compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.92 [0.8, 1.06]
  5 studies · 2759 participants
  Low

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality: patients with AKI not related to surgery compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.94 [0.73, 1.2]
  3 studies · 1871 participants
  Low

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive leads to lower mortality: patients with AKI related to cardiac or general surgery compared with less intensive continuous renal replacement therapy (CRRT) (high certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.73 [0.61, 0.88]
  2 studies · 531 participants
  High

Intensive glycaemic control vs conventional glucose control

Intensive glucose control showed no clear difference in all‐cause mortality compared with conventional glucose control (moderate certainty).

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  OR 1.02 [0.48, 2.19]
  10 studies · 2039 participants
  Moderate

Intensive glycaemic control vs conventional glucose control

Intensive glycaemic control showed no clear difference in mortality compared with standard glycaemic control (moderate certainty).

• Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia 2017 · Cochrane Headline outcomes only
  RR 1 [0.79, 1.26]
  3 studies · 15888 participants
  Moderate
• Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus 2013 · Cochrane Headline outcomes only
  RR 1 [0.92, 1.08]
  24 studies · 34325 participants
  Moderate

Intensive glycaemic control vs conventional glucose control

Intensive glycaemic control showed no clear difference in cardiovascular mortality compared with conventional glycaemic control (moderate certainty).

• Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus 2013 · Cochrane Headline outcomes only
  RR 1.06 [0.94, 1.21]
  22 studies · 34177 participants
  Moderate

Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise

• Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 450 participants
  Very low

Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise

The review found no eligible studies for this question.

• Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intermittent ausculation of fetal heart rate in labour for fetal well‐being ‐ Intensive Pinard vs routine Pinard (outcomes

It is very uncertain whether intermittent ausculation of fetal heart rate in labour for fetal… changes perinatal mortality compared with routine Pinard (outcomes (very low certainty).

• Intermittent auscultation (IA) of fetal heart rate in labour for fetal well‐being 2017 · Cochrane Headline outcomes only
  RR 0.56 [0.19, 1.67]
  1 study · 625 participants
  Very low

Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention

• Blood pressure control for diabetic retinopathy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 participants
  GRADE not reported

Intermittent ausculation of fetal heart rate in labour for fetal well‐being ‐ Intensive Pinard vs routine Pinard (outcomes

• Intermittent auscultation (IA) of fetal heart rate in labour for fetal well‐being 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported