Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

249 questions · 258 findings · 25 reviews

No studies found 52 · 20.2%GRADE not reported 8 · 3.1%Very low 71 · 27.5%Low 56 · 21.7%Moderate 61 · 23.6%High 10 · 3.9%

Early inhaled steroids (< 2 weeks) vs placebo (among survivors)

CLD at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroid (< 2 weeks) probably leads to lower CLD at 36 weeks' PMA compared with placebo (among survivors) (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Oxygen requirement at 36 weeks' postmenstrual age · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) showed no clear difference in CLD at 36 weeks' PMA oxygen dependency at 36 weeks' PMA compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) probably leads to lower death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36… compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Short‐acting inhaled beta‐2 agonists vs placebo

Number of exacerbations(as reported by number of hospitalisations and number of courses and days on antibiotics) · adults and children with cystic fibrosis

It is very uncertain whether short‐acting inhaled beta‐2 agonists changes number of exacerbations(as reported by number of hospitalisations… compared with placebo (very low certainty).

1 finding from 1 review

Short‐acting inhaled beta‐2 agonists vs placebo

Participant‐reported symptom score: cough, wheeze and exercise tolerance · adults and children with cystic fibrosis

It is very uncertain whether short‐acting inhaled beta‐2 agonists changes participant‐reported symptom score: cough, wheeze and exercise… compared with placebo (very low certainty).

1 finding from 1 review