Smoking cessation · people who smoke
Higher‐dose showed no clear difference in smoking cessation ‐ 42/44 mg versus 21/22 mg (24‐hour patches) compared with lower‐dose nicotine patch (moderate certainty).
3 findings from 1 review
RR 1.09 [0.93, 1.29]
5 studies · 1655 participants
Moderate
RR 1.19 [1, 1.41]
3 studies · 3446 participants
Moderate
RR 1.48 [1.06, 2.08]
1 study · 537 participants
Moderate
SAEs · people who smoke
Higher‐dose showed no clear difference in overall SAEs ‐ 42/44 mg versus 21/22 mg (24 hr patches) compared with lower‐dose nicotine patch (low certainty).
2 findings from 1 review
Treatment withdrawal · people who smoke
Higher‐dose may leads to higher treatment withdrawals ‐ 42/44 mg versus 21/22 mg (24‐hour patches) compared with lower‐dose nicotine patch (low certainty).
1 finding from 1 review
Treatment withdrawals ‐ 21 mg versus 14 mg (24‐hour patches) · people who smoke
Higher‐dose showed no clear difference in treatment withdrawals ‐ 21 mg versus 14 mg (24‐hour patches) compared with lower‐dose nicotine patch (low certainty).
1 finding from 1 review
Total VTE · people undergoing bariatric surgery
Higher‐dose heparin showed no clear difference in VTE compared with standard‐dose heparin (low certainty).
1 finding from 1 review
Major bleeding · people undergoing bariatric surgery
Higher‐dose heparin showed no clear difference in major bleeding compared with standard‐dose heparin (low certainty).
1 finding from 1 review
All‐cause mortality · people undergoing bariatric surgery
1 finding from 1 review
VTE‐related mortality4 · people undergoing bariatric surgery
1 finding from 1 review
PE · people undergoing bariatric surgery
It is very uncertain whether higher‐dose heparin changes PE compared with standard‐dose heparin (very low certainty).
1 finding from 1 review
Deep vein thrombosis · people undergoing bariatric surgery
It is very uncertain whether higher‐dose heparin changes DVT compared with standard‐dose heparin (very low certainty).
1 finding from 1 review
Thrombocytopenia · people undergoing bariatric surgery
It is very uncertain whether higher‐dose heparin changes adverse events (thrombocytopenia) compared with standard‐dose heparin (very low certainty).
1 finding from 1 review
Food intake · cancer cachexia in adults
1 finding from 1 review
Weight (kg) · cancer cachexia in adults
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Adverse events · cancer cachexia in adults
1 finding from 1 review
All‐cause mortality · people hospitalised with COVID‐19
Higher‐dose anticoagulants showed no clear difference in all‐cause mortality compared with lower‐dose anticoagulants (high certainty).
1 finding from 1 review
Necessity for additional respiratory support · people hospitalised with COVID‐19
It is very uncertain whether higher‐dose anticoagulants changes necessity for additional respiratory support compared with lower‐dose anticoagulants (very low certainty).
1 finding from 1 review
Mortality related to COVID‐19 · people hospitalised with COVID‐19
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Deep vein thrombosis · people hospitalised with COVID‐19
Higher‐dose anticoagulants showed no clear difference in deep vein thrombosis compared with lower‐dose anticoagulants (low certainty).
1 finding from 1 review
Pulmonary embolism · people hospitalised with COVID‐19
Higher‐dose anticoagulants probably leads to lower pulmonary embolism compared with lower‐dose anticoagulants (moderate certainty).
1 finding from 1 review
Major bleeding · people hospitalised with COVID‐19
Higher‐dose anticoagulants probably leads to higher major bleeding compared with lower‐dose anticoagulants (moderate certainty).
1 finding from 1 review