Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

637 questions · 714 findings · 96 reviews

No studies found 98 · 13.7%GRADE not reported 191 · 26.8%Very low 157 · 22%Low 161 · 22.5%Moderate 87 · 12.2%High 20 · 2.8%

High‐intensity brief text messaging (SMS) vs low‐intensity brief text messaging

Documenting of matched pregnancy outcome data · Community health care workers, known as Health Surveillance Assistants (HSAs) (n = 156) associated with 30 health facilities.

High‐intensity brief text messaging (SMS) showed no clear difference in documenting of matched pregnancy outcome data compared with low‐intensity brief text messaging (low certainty).

1 finding from 1 review

High‐intensity brief text messaging (SMS) vs low‐intensity brief text messaging

Functioning of the RHIS · Community health care workers, known as Health Surveillance Assistants (HSAs) (n = 156) associated with 30 health facilities.

The review found no eligible studies for this question.

1 finding from 1 review

High‐intensity brief text messaging (SMS) vs low‐intensity brief text messaging

Health provider outcomes · Community health care workers, known as Health Surveillance Assistants (HSAs) (n = 156) associated with 30 health facilities.

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D (higher dose) + micronutrient(s) vs vitamin D (lower dose) + micronutrient(s)

Adverse effect: hypercalciuria As defined by trialists Time frame: 3 months · children under 5 years of age

Vitamin D (higher dose) + micronutrient(s) showed no clear difference in adverse effect: hypercalciuria As defined by trialists Time frame: 3… compared with vitamin D (lower dose) + micronutrient(s) (low certainty).

1 finding from 1 review

Vitamin D (higher dose) + micronutrient(s) vs vitamin D (lower dose) + micronutrient(s)

Hypercalcaemia · children under 5 years of age

Vitamin D (higher dose) + micronutrient(s) showed no clear difference in adverse effect: hypercalcaemia As defined by trialists Time frame:… compared with vitamin D (lower dose) + micronutrient(s) (moderate certainty).

1 finding from 1 review

Summary of findings: Higher bladder volume vs lower bladder volume

Acute and late GI toxicity (grade 2+) · Men undergoing RT for prostate cancer

Summary of findings: Higher bladder volume showed no clear difference in acute and late GI toxicity (grade 2+) compared with lower bladder volume (low certainty).

1 finding from 1 review

Higher family income / socioeconomic status vs Lower income / worse socioeconomic status

Oral health-related quality of life · Adolescents (10-19 years)

Higher family income / better socioeconomic status is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

1 finding from 1 review
  • Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
    Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
    Adolescents from families with higher incomes and higher levels of maternal education have better OHRQoL scores [34]. Worse oral health status, older age, female sex and worse socioeconomic status were significantly…
    Studies not reported
    GRADE not reported

Higher circulating 1,25-dihydroxyvitamin D (1,25(OH)2D) concentration vs Lower circulating 1,25-dihydroxyvitamin D (1,25(OH)2D) concentration

Prostate cancer · Participants in observational studies

The meta-analysis of observational studies reported a OR of 0.99 (95% CI 0.87 to 1.12) for higher versus lower circulating vitamin D concentration.

1 finding from 1 review

Higher circulating 1,25-dihydroxyvitamin D (1,25(OH)2D) concentration vs Lower circulating 1,25-dihydroxyvitamin D (1,25(OH)2D) concentration

Breast cancer · Participants in observational studies

The meta-analysis of observational studies reported a OR of 0.99 (95% CI 0.68 to 1.47) for higher versus lower circulating vitamin D concentration.

1 finding from 1 review

Higher BMI (continuous / per-unit increment) vs Lower BMI (continuous reference / per 1 kg/m2 decrement)

Dental caries in children · Children (approx. 4-18 years)

Pooling studies that used BMI as a continuous variable showed no significant association between per-unit BMI and childhood dental caries (OR 1.01, 95% CI 0.99 to 1.03; I2=3.5%); ungraded.

3 findings from 1 review