Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

155 questions · 185 findings · 21 reviews

No studies found 48 · 25.9%GRADE not reported 26 · 14.1%Very low 30 · 16.2%Low 54 · 29.2%Moderate 23 · 12.4%High 4 · 2.2%

Summary of findings: high‐dose urate oxidase vs low‐dose urate oxidase

Serum urate normalisation ‐ not reported · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: high‐dose urate oxidase showed no clear difference in normalisation of serum uric acid ( compared with low‐dose urate oxidase (low certainty).

1 finding from 1 review

Summary of findings: high‐dose urate oxidase vs low‐dose urate oxidase

Frequency of adverse events ( · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: high‐dose urate oxidase showed no clear difference in frequency of adverse events ( compared with low‐dose urate oxidase (low certainty).

1 finding from 1 review