Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

279 questions · 295 findings · 26 reviews · Headline outcomes only

No studies found 74 · 25.1%GRADE not reported 23 · 7.8%Very low 77 · 26.1%Low 82 · 27.8%Moderate 28 · 9.5%High 11 · 3.7%

Heparin vs normal saline solution locking

Occlusion of CVC (combining participant and catheter as unit of analysis) Blood withdrawing · adults with CVCs

Heparin may leads to lower occlusion of CVC (combining participant, and catheter as unit of… compared with normal saline solution locking (low certainty).

1 finding from 1 review

Heparin vs normal saline solution locking

CVC‐related bloodstream infections (positive microbiological culture, participant as unit of analysis) · adults with CVCs

It is very uncertain whether heparin changes CVC‐related bloodstream infections (positive microbiological… compared with normal saline solution locking (very low certainty).

1 finding from 1 review