What do systematic reviews say?

Gonadotrophins vs continued clomiphene citrate

Gonadotrophins probably leads to higher live birth rate per woman compared with continued clomiphene citrate (moderate certainty).

• Gonadotrophins for ovulation induction in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
  RR 1.24 [1.05, 1.46]
  1 study · 661 participants
  Moderate

Gonadotrophins vs continued clomiphene citrate

Gonadotrophins showed no clear difference in incidence of multiple pregnancy per woman compared with continued clomiphene citrate (moderate certainty).

• Gonadotrophins for ovulation induction in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
  RR 0.89 [0.33, 2.4]
  1 study · 661 participants
  Moderate

Gonadotrophins vs continued clomiphene citrate

Gonadotrophins probably leads to higher clinical pregnancy rate per woman compared with continued clomiphene citrate (moderate certainty).

• Gonadotrophins for ovulation induction in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
  RR 1.31 [1.13, 1.52]
  1 study · 661 participants
  Moderate

Gonadotrophins vs continued clomiphene citrate

Gonadotrophins may leads to higher miscarriages per woman compared with continued clomiphene citrate (low certainty).

• Gonadotrophins for ovulation induction in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
  RR 2.23 [1.11, 4.47]
  1 study · 661 participants
  Low

Gonadotrophins vs continued clomiphene citrate

• Gonadotrophins for ovulation induction in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 661 participants
  Low

Gonadotrophins vs placebo/no treatment

It is very uncertain whether gonadotrophins changes live birth rate per couple randomly assigned compared with placebo/no treatment (very low certainty).

• Gonadotrophins for idiopathic male factor subfertility 2013 · Cochrane Headline outcomes only
  OR 9.31 [1.17, 73.75]
  1 study · 30 participants
  Very low

Gonadotrophins vs placebo/no treatment

Gonadotrophins probably leads to higher spontaneous pregnancy rate per couple randomly assigned compared with placebo/no treatment (moderate certainty).

• Gonadotrophins for idiopathic male factor subfertility 2013 · Cochrane Headline outcomes only
  OR 4.94 [2.13, 11.44]
  5 studies · 412 participants
  Moderate

Gonadotrophins with anti‐oestrogens vs gonadotropins alone

Gonadotrophins with anti‐oestrogens showed no clear difference in multiple pregnancy rate per couple compared with gonadotropins alone (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 3.03 [0.12, 75.06]
  1 study · 230 participants
  Low

Gonadotrophins with anti‐oestrogens vs gonadotropins alone

It is very uncertain whether gonadotrophins with anti‐oestrogens changes clinical pregnancy rate per couple compared with gonadotropins alone (very low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 1.99 [0.81, 4.9]
  2 studies · 328 participants
  Very low

Gonadotrophins with anti‐oestrogens vs gonadotropins alone

Gonadotrophins with anti‐oestrogens showed no clear difference in OHSS rate per couple compared with gonadotropins alone (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 0.5 [0.04, 5.54]
  1 study · 230 participants
  Low