Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

55 questions · 56 findings · 4 reviews · Headline outcomes only

No studies found 0 · 0%GRADE not reported 7 · 12.5%Very low 25 · 44.6%Low 24 · 42.9%Moderate 0 · 0%High 0 · 0%

Fish oil lipid emulsion (LE) vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – pure F‐LE vs S‐LE · parenterally fed term and late preterm infants with surgical conditions

It is very uncertain whether fish oil LE changes PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) Pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Resolution of PNALD/cholestasis (conjugated bilirubin less than2 mg/dL) Pure F‐LE vs S‐LE · parenterally fed term and late preterm infants

It is very uncertain whether fish oil LE changes resolution of PNALD/cholestasis (conjugated bilirubin less than2… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Any sepsis (clinical and/or culture positive) · parenterally fed term and late preterm infants

It is very uncertain whether fish oil LE changes any sepsis (clinical or culture positive (or both)) MOFS‐LE vs S‐LE… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review