Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

13 questions · 13 findings · 3 reviews · Skin

No studies found 6 · 46.2%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 7.7%Moderate 2 · 15.4%High 4 · 30.8%

Etanercept vs placebo

Proportion of participants cleared or almost cleared ‐ · chronic palmoplantar pustulosis

Etanercept showed no clear difference in proportion of participants cleared or almost cleared in the short… compared with placebo (low certainty).

1 finding from 1 review

Etanercept vs placebo

Proportion of participants with adverse effects serious or severe enough to have caused withdrawal ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Etanercept vs placebo

Proportion of participants with at least 50% improvement in their quality of life ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Etanercept vs placebo

Proportion of participants achieving a 50% reduction in disease severity ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Etanercept vs placebo

Proportion of participants without relapse in the long term ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Etanercept vs placebo

Percentage of participants reaching PASI 75 · people with paediatric psoriasis

Etanercept leads to higher PASI 75 Participants achieving a 75% improvement in the Psoriasis… compared with placebo (high certainty).

1 finding from 1 review

Etanercept vs placebo

PASI 50 · people with paediatric psoriasis

Etanercept leads to higher PASI 50 Participants achieving a 50% improvement in the Psoriasis… compared with placebo (high certainty).

1 finding from 1 review

Etanercept vs placebo

PASI 90 · people with paediatric psoriasis

Etanercept leads to higher PASI 90 Participants achieving a 90% improvement in the Psoriasis… compared with placebo (high certainty).

1 finding from 1 review

Etanercept vs placebo

PGA Participants achieving a PGA of 'clear' or 'almost clear' · people with paediatric psoriasis

Etanercept leads to higher PGA Participants achieving a PGA of 'clear' or 'almost clear' compared with placebo (high certainty).

1 finding from 1 review

Etanercept vs placebo

CDLQI Scores range from 0 to 30. Lower scores indicate better health‐related quality of life. Calculations are based on the change from baseline to week 12 in both groups · people with paediatric psoriasis
1 finding from 1 review