Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

91 questions · 91 findings · 11 reviews

No studies found 15 · 16.5%GRADE not reported 2 · 2.2%Very low 19 · 20.9%Low 28 · 30.8%Moderate 19 · 20.9%High 8 · 8.8%

Regional (spinal, epidural, caudal) vs general anaesthesia

Apnoea/bradycardia occurring 12‐24 hours following completion of operation · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) showed no clear difference in apnoea/bradycardia occurring 12‐24 hours following completion of… compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Any oxygen desaturation occurring 12‐24 hours following completion of the operation · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) showed no clear difference in any oxygen desaturation occurring 12‐24 hours following completion… compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Use of post‐operative respiratory support · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) showed no clear difference in use of post‐operative respiratory support compared with general anaesthesia (low certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Post‐operative apnoea with preoperative sedatives excluded · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) probably leads to lower post‐operative apnoea with preoperative sedatives excluded compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Anaesthetic agent failure · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) may leads to higher anaesthetic agent failure compared with general anaesthesia (low certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Anaesthetic placement failure · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) showed no clear difference in anaesthetic placement failure compared with general anaesthesia (low certainty).

1 finding from 1 review

Thoracic epidural anaesthesia vs conventional pain control

Persistent pain 3 to 18 months after thoracotomy (We defined persistent postsurgical pain as new pain that did not exist before the operation, measured using differences in scores based on validated pain scales; patient interview between 3 to 18 m... · Patients undergoing thoracotomy

Thoracic epidural anaesthesia probably leads to lower persistent pain 3 to 18 months after thoracotomy (We defined… compared with conventional pain control (moderate certainty).

1 finding from 1 review

Epidural anaesthesia in addition to general anaesthesia vs general anaesthesia

Death from all causes Range of · patients undergoing primary tumour surgery

Epidural anaesthesia in addition to general anaesthesia showed no clear difference in death from all causes Range of compared with general anaesthesia alone (low certainty).

1 finding from 1 review

Epidural anaesthesia in addition to general anaesthesia vs general anaesthesia

Tumour progression or death from all causes Range of · patients undergoing primary tumour surgery

It is very uncertain whether epidural anaesthesia in addition to general anaesthesia changes tumour progression or death from all causes Range of compared with general anaesthesia alone (very low certainty).

1 finding from 1 review

Epidural anaesthesia in addition to general anaesthesia vs general anaesthesia

Tumour progression Median · patients undergoing primary tumour surgery

It is very uncertain whether epidural anaesthesia in addition to general anaesthesia changes tumour progression Median compared with general anaesthesia alone (very low certainty).

1 finding from 1 review