Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

62 questions · 62 findings · 7 reviews

No studies found 15 · 24.2%GRADE not reported 0 · 0%Very low 14 · 22.6%Low 16 · 25.8%Moderate 12 · 19.4%High 5 · 8.1%

Epidural analgesia vs systemic analgesia

Complications · children having undergone thoraco‐lumbar spine surgery. 3 trials included in the analysis contained participants older than 18 years:…

It is very uncertain whether epidural analgesia changes complications compared with systemic analgesia (very low certainty).

1 finding from 1 review

Epidural analgesia vs intravenous patient‐controlled analgesia

All‐cause mortality rate at 30 days · adults having abdominal surgery

Epidural analgesia showed no clear difference in all‐cause mortality rate at 30 days compared with intravenous patient‐controlled analgesia (low certainty).

1 finding from 1 review

Epidural analgesia vs intravenous patient‐controlled analgesia

Failure of analgesic technique requiring alternative approach (assessed at any time) · adults having abdominal surgery

Epidural analgesia probably leads to higher failure of analgesic technique requiring alternative approach… compared with intravenous patient‐controlled analgesia (moderate certainty).

1 finding from 1 review

Epidural analgesia vs intravenous patient‐controlled analgesia

Adverse events (assessed at any time during · adults having abdominal surgery

Epidural analgesia showed no clear difference in adverse events (assessed at any time during compared with intravenous patient‐controlled analgesia (low certainty).

1 finding from 1 review

Early initiation of epidural analgesia vs Late initiation

Caesarean section · pregnant women (at term) requesting epidural analgesia in labour (regardless of whether the labour was spontaneous or induced)

Early initiation of epidural analgesia showed no clear difference in caesarean section compared with late initiation (high certainty).

1 finding from 1 review

Early initiation of epidural analgesia vs Late initiation

Instrumental delivery · pregnant women (at term) requesting epidural analgesia in labour (regardless of whether the labour was spontaneous or induced)

Early initiation of epidural analgesia showed no clear difference in instrumental delivery compared with late initiation (high certainty).

1 finding from 1 review

Early initiation of epidural analgesia vs Late initiation

Apgar score less than 7 at 5 minutes · pregnant women (at term) requesting epidural analgesia in labour (regardless of whether the labour was spontaneous or induced)

Early initiation of epidural analgesia showed no clear difference in apgar score <7 at 5 min compared with late initiation (high certainty).

1 finding from 1 review

Epidural analgesia vs peripheral nerve blocks

Duration of tracheal intubation · adults undergoing cardiac surgery without cardiopulmonary bypass

It is very uncertain whether epidural analgesia changes duration of tracheal intubation compared with peripheral nerve blocks (very low certainty).

1 finding from 1 review