Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

32 questions · 32 findings · 5 reviews · Neonatal

No studies found 2 · 6.3%GRADE not reported 1 · 3.1%Very low 6 · 18.8%Low 15 · 46.9%Moderate 5 · 15.6%High 3 · 9.4%

Late parenteral nutrition vs early parenteral nutrition

Healthcare‐associated blood stream infection · critically ill term and late preterm infants

Late parenteral nutrition showed no clear difference in healthcare‐associated blood stream infection compared with early parenteral nutrition (low certainty).

1 finding from 1 review

Enteral zinc supplementation vs no zinc supplementation

All‐cause mortality (between start of intervention and end of · preterm infants

Enteral zinc supplementation may leads to lower all‐cause mortality (between start of intervention and end of compared with no zinc supplementation (low certainty).

1 finding from 1 review

Lactoferrin supplementation with enteral feeds in combination with probiotics vs placebo

All‐cause mortality · prevention of sepsis and necrotizing enterocolitis in preterm infants

It is very uncertain whether lactoferrin supplementation with enteral feeds in combination with… changes all‐cause mortality compared with placebo (very low certainty).

1 finding from 1 review

Lactoferrin supplementation with enteral feeds in combination with probiotics vs placebo

Bacterial sepsis · prevention of sepsis and necrotizing enterocolitis in preterm infants

Lactoferrin supplementation with enteral feeds in combination with… may leads to lower bacterial sepsis compared with placebo (low certainty).

1 finding from 1 review